摘要
目的探讨2型糖尿病(T2DM)患者肿瘤坏死因子α(TNF-α)、高敏C反应蛋白(hsC-RP)与尿白蛋白排泄率的相关性。方法将302例T2DM患者根据尿白蛋白排泄率(UAER)进行分组。采用多元相关和逐步回归分析评价TNF-α、hsC-RP对UAER的影响。结果随着UAER的增加,TNF-α、hsC-RP水平升高。TNF-α和hsC-RP与UAER显著正相关(P<0.01)。结论 T2DM患者TNF-α、hsC-RP水平与UAER关系密切。
Objective To investigate the relation of the tumor necrosis factor-alpha and C-reaction protein with UAER in type 2 diabetes. Methods The 302 subjects with type 2 diabetes were stratified according to UAER levels. The levels of TNF-α and hsCRP were measured. Demographic and potential metabolic confounding factors were analyzed with muhivariable correlate analysis and stepwise regression analysis to evaluate the effects of the levels of TNF-α and hsCRP on UAER. Results With the increase of UAER, the levels of TNF-α and hsCRP were gradually increased. TNF-α and hsCRP were positively related to UAER（P〈0. 001）. Conclusions The levels of TNF-α and hsCRP are related with UAER in subjects with type 2 diabetes in a dose-dependent manner.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2010年第9期677-678,共2页
Chinese Journal of Diabetes
关键词
糖尿病
2型
肿瘤坏死因子Α
高敏C反应蛋白
白蛋白尿
Diabetes mellitus, type 2
Tumor necrosis factor-alpha
High sensitivity C-reactive protein
Albuminuria
