摘要
目的 观察纳洛酮联合山莨菪碱治疗急性酒精中毒的临床疗效. 方法 78例急性酒精中毒患者按入院单双号随机分为对照组（35例）和治疗组（43例）,对照组采用纳洛酮治疗,治疗组采用纳洛酮联合山莨菪碱治疗,比较两组临床治疗效果及不良反应发生情况. 结果 两组经治疗后症状均得到缓解,治疗组起效时间（12.8±6.1）min、症状减轻时间（32.4±8.7）min、症状消失时间（5.8±2.6）h,明显短于对照组的（15.7±5.5）min、（41.7±6.9）min、（7.1±3.1）h（t=3.64、4.01、3.52,均P＜0.05）;两组均未发生严重不良反应. 结论 纳洛酮联合山莨菪碱治疗急性酒精中毒可显著缩短酒精中毒持续时间,起到更好的治疗效果.
Objective To observe the curative effect of naloxone and anisodamine in the therapy of acute alcoholism. Methods 78 patients with acute alcoholism were randomly divided into control group（35 patients treated with naloxone）and treatment group（43 patients treated with naloxone combination with anisodamine）.The curative effects were observed in the two groups. Results The symptoms were relieved and disappeared in the two groups.The effects began quickly in the treatment group than that in control group.The symptomatic relief time and extinction time in the treatment group were significantly shorter than that in the control group（t=3.64,4.01,3.52,all P 〈0.05）.Conclusiou Naloxone combination with anisodamine could significantly shorten the endurance time of alcoholism.It might be a useful method in the therapy of acute alcoholism.
出处
《中国基层医药》
CAS
2010年第16期2194-2195,共2页
Chinese Journal of Primary Medicine and Pharmacy
