摘要
目的评估危重病人应用肠外营养（ＰＮ）加重组生长激素（ｒｈＧＨ），对降低并发症发生率和病死率，促进蛋白质合成及改善负氮平衡的作用。方法随机入组４５例，ＰＮ＋ｒｈＧＨ组１５例，ＰＮ作为对照组３０例。热量提供１４６３ｋＪ／（ｋｇ·ｄ），氮量０３ｇ／（ｋｇ·ｄ）。ｒｈＧＨ１２Ｕ／ｄ，皮下注射５～１２天。结果治疗１４天后，血ＧＨ及胰岛素水平在ＰＮ＋ｒｈＧＨ组较对照组明显升高，组间比差异有明显的统计学意义。血糖在ＰＮ＋ｒｈＧＨ组虽较对照组升高，但组间比差异无统计学意义。治疗前后血浆白蛋白水平，两组均明显降低，组间比无差异。而前白蛋白、转铁蛋白及负氮平衡改善ＰＮ＋ｒｈＧＨ组明显高于对照组。治疗后呼吸机使用日，组间比差异无统计学意义；并发症的发生率和病死率，组间比差异有显著性意义。结论ＰＮ＋ｒｈＧＨ支持治疗可改善危重病人预后，降低并发症的发生率和病死率。
Objective The purpose of this study was to determine if recombinant growth hormone(rhGH)given with parenteral nutrition(PN)could promote synthesis and enhance nitrogen retention,and to determine if this therapy could reduce the incidence of the complication and mortality in critically ill patients.Methods Fourty-five patients was randomized to two groups,both groups received standard PN providing 146 3kJ/(kg·d) and 0 2gN/(kg·d).In addition,PN+rhGH group( n =15)received subcutaneous injections of rhGH at a dose of 12 IU daily for 5～12 days.Results pre- and postintervention,serum proteins were decreased in both groups,there was no difference between them,but pre-albumin,transferrin and negative N balance were increased in PN+rhGH group than in control.There was no difference in the maintenance period of the ventilator support between two groups.The incidence of the complications and mortality were significantly lower in PN+rhGH group than in control.Conclusion PN+rhGH could significantly improve the clinical outcome,deercase the incidence of complications and mortality in critically ill patients.
出处
《中国实用外科杂志》
CSCD
北大核心
1999年第5期285-286,共2页
Chinese Journal of Practical Surgery
