摘要
目的探讨针刺治疗对烧伤增生性瘢痕血管内皮细胞生长因子(VEGF)和血管内皮抑素的影响。方法选择双侧肢体有对称性瘢痕增生的大面积深度烧伤康复期患者20例,梅花针针刺治疗一侧肢体,对侧常规治疗作为对照,评价针刺治疗效果。并且于治疗前、治疗后及6个月各取瘢痕组织标本,检测各组瘢痕组织中VEGF、血管内皮抑素的表达。结果与对照组比较,针刺侧瘢痕增生表现轻、VEGF表达降低(P<0.05)。结论针刺治疗对烧伤增生性瘢痕的防治作用优于常规抗瘢痕治疗,可能与针刺治疗后增生性瘢痕内VEGF表达降低有关。
Objective To study the effect of acupuncture therapy with dermal-needle on vascular endothelial growth factor（VEGF） and endostatin in hypertrophic scar（HS）.MethodsTwenty HS patients on both sides of the limbs symmetrically were selected to be treated with dermal-needle on one side and conventioal treatment on the other side as the control.The efficacy of treatment was observed and compared.The expressions of VEGF and endostatin in the scars were detected by immunohistochemical method.Results Compared to the control sides,the proliferative manifestation was lighter and VEGF expression was less on the dermal-needle treating sides after treatment for three to six months（P0.05）.Conclusion The efficacy of dermal-needle treatment is better than conventional therapy in preventing and treating HS,which may be ralated to a reduction of VEGF expression in hypertrophic scar.
出处
《江苏医药》
CAS
CSCD
北大核心
2010年第16期1888-1891,F0002,共5页
Jiangsu Medical Journal
关键词
增生性瘢痕
梅花针
血管内皮细胞生长因子
血管内皮抑素
Hypertrophic scar
Dermal needle acupuncture
Vascular endothelial growth factor
Endostatin
