摘要
目的选取多个炎症因子—基质金属蛋白酶抑制剂1(TIMP1),基质金属蛋白酶9(MMP9),新蝶呤(Neopterin),观察其在急性心肌梗死(AMI),不稳定性心绞痛、稳定性心绞痛和正常人群中的不同表达水平以及与传统心肌损伤标志物之间的相互关系,以期探索其在AMI发病进展过程中的作用和用于预测急性心梗风险的可行性。方法从收住本院的患者中,入选AMI51例,不稳定性心绞痛48例,稳定性心绞痛54例,正常人44例。所有患者的确诊依据世界卫生组织诊断标准和中华医学会的相关指南。所有患者均接受冠脉造影检查,同时采集血标本。用ELISA法分别测定4组患者的MMP9,TIMP1和Neopterin浓度。所得数据使用SPSS统计软件处理,以P<0.05作为有统计学意义的显著性差异。各个数据之间的相关采用单回归线性分析检验。结果 (1)基本临床资料:四组之间在年龄和高血脂,糖尿病发病率上无显著性差异,正常组男性,高血压和吸烟史相对其他组较少。稳定心绞痛和不稳定心绞痛高血压的发生率高于急性心梗。(2)传统的心肌损伤标志物和炎症因子检测结果:高敏C反应蛋白,肌酸激酶,肌酸激酶同工酶和肌钙蛋白I,急性心梗组皆高于其他3个组,有显著性差异。而其他三组之间并无显著性差异。(3)其他炎症因子检测结果:,MMP9、TIMP1、MMP9/TIMP1以及Neopterin各个指标,AMI组皆高于其他3组,有显著性差异。其他三个组相互之间并无显著性差异。(4)入选病人的Hs-CRP与Neopterin和CK呈良好的正相关性(P<0.05),而MMP9/TIMP1与hs-CRP及CK皆无相关性。Neopterin与CK也无相关性。结论在AMI患者,炎症因子MMP9、TIMP1、Neopterin均明显升高,除Neopterin与Hs-CRP有良好相关性以外,其他的炎症因子与传统的心肌损伤标志物并无相关性。
Objective we selected several inflammation biomaker ,such as TIMP1,MMP9, Neopterin,and observed concentration levels in patients with acute myocardial infarction, unstable angina, stable angina and normal.Methods 197 patients were chosen, and was divided into 4 groups-acute myocardial infarction group（51 patients）, unstable angina group （48 patients）, stable angina（54 patients）, and normal group（44 patients）.All patients were to make a definite diagnosis by WTO and Chinese Medical Association guideline. The blood plasma was collected and concentration was assayed by ELISA. Statistical analysis was performed using SAS software methods for small samples. A P value〈0.05 was considered statistically significant. Result （1） Clinical characteristics： There were no significant differences in age and the prevalence of hyperlipemia and diabetes mellitus. In normal group, there were less men, hypertension and smoke history. （2）In AMI groups, there were a higher levels in Hs-CRP,CK,CK –MB and CTnI. There were no significant differences in traditional myocardial infarction biomarker between other three groups. （3） In AMI groups ,there were a higher levels in MMP9.TIMP1.MMP9/TIMP1 and neopterin. There were no significant differences in inflammation biomarker between other three groups.（4）There were a association between Hs-CRP and neopterin ,CK（P〈0.05）. Conclusion In AMI groups ,the inflammation biomakers（MMP9,TIMP1, neopterin） were significant elevated. There was an association between Hs-CRP and neopterin. There were no correlation between other inflammation biomarkers and traditional myocardial infarction biomarkers.
出处
《中国分子心脏病学杂志》
CAS
2010年第4期213-216,共4页
Molecular Cardiology of China
关键词
急性心梗
心梗标记物
炎症因子
Acute myocardial infarction
Myocardial infarction biomaker
Markers of inflammation
