摘要
骨质疏松性骨折是骨质疏松最严重的并发症,在治疗骨折的同时还需要抗骨质疏松治疗,但这些药物是否干扰骨折愈合以及骨折后是否可以使用,如何使用?临床争议较大。本文的主要是对抗骨质疏松药物对骨质疏松性骨折愈合的影响进行概述。抗骨质疏松的药物可以分为:膳食补充剂、抗骨吸收药物、促进骨形成药物和同时具备这两种效果的双重作用药物,以及最近尚在研究的一些新药物。众多学者对抗骨质疏松药物对骨质疏松性骨折愈合的影响做了大量的研究,大多数临床和实验室的证据表明治疗骨质疏松药物对骨质疏松性骨折的愈合有中性的或者积极的影响,但也有些研究得出不同的结论,归纳和总结这些结论将对骨质疏松性骨折的药物治疗具有一定的临床指导意义。
Osteoporotic fracture is the most serious complication of osteoporosis. Anti-osteoporosis therapy should be conducted at the same time to treat the fracture. However, there are some clinical controversies on whether these drugs interfere the fracture healing, whether these drugs could be used after fracture, and how the drugs could be used. The paper presents an overview on the effect of anti-osteoporosis drugs on osteoporotic fracture healing. Anti-osteoporosis drugs can be divided into the following： dietary supplement, anti-absorption drugs, bone-formation stimulating drugs, drugs combined with the effect of anti-absorption and bone formation stimulating, and new drugs being developed. Many scholars have conducted a lot of research on the effect of anti-osteoporosis drugs on osteoporotic fracture healing. Most of the clinical and laboratory evidences indicate that anti-osteoporosis drugs have neutral or positive effects on fracture healing. However, some studies provide different conclusions. The summary of these conclusions could give certain clinical significance to the drug treatment of osteoporotic fracture.
出处
《中国骨质疏松杂志》
CAS
CSCD
2010年第8期606-610,570,共6页
Chinese Journal of Osteoporosis
