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蛋白质组学在垂体腺瘤差异表达蛋白检测中的应用进展

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摘要 双向聚丙烯酰胺凝胶电泳与质谱技术、生物信息学的结合,使得将蛋白质组学技术应用于临床肿瘤的研究中成为可能。比较蛋白质组学中的很多方法已经应用于肿瘤研究的不同领域。垂体腺瘤是临床常见颅内良性肿瘤,因激素分泌异常和肿瘤占位压迫引起一系列临床症状。应用比较蛋白质组学研究垂体腺瘤,发现差异表达蛋白质,并对这些差异表达蛋白质的翻译后修饰,尤其是对磷酸化修饰方面进行深入研究,有望为研究垂体腺瘤的分子发生机制、生物标志物、早期诊断和治疗提供新的思路。
作者 范长燕 孙青芳
机构地区 上海交通大学医学院附属瑞金医院神经外科
出处 《中国微侵袭神经外科杂志》 CAS 北大核心 2010年第8期381-384,共4页 Chinese Journal of Minimally Invasive Neurosurgery
基金 上海市自然科学基金(编号:Z08ZR1413)
关键词 垂体肿瘤 蛋白质组学 差异表达 检测
分类号 R736.4 [医药卫生—肿瘤]
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参考文献24

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中国微侵袭神经外科杂志
2010年 第8期

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