摘要
目的探讨转化生长因子—βｓ族（ＴＧＦ－β１，２，３和肿瘤坏死因子－α（ＴＮＦ－α）在瘢痕形成中的作用；方法以免疫组化法检测４７例不同类型瘢痕组织和１６例正常皮肤组织中ＴＧＦ－βｓ和ＴＮＦ－α的表达，并按瘢痕的不同类型、不同病程、患者的年龄和性别分组进行比较；结果（１）ＴＧＦ－βｓ在正常皮肤组织中无免疫阳性表达；（２）ＴＧＦ－β１２在增生性瘢痕中表达较强，并在病程１ａ以上、甚至５ａ的增生性瘢痕中仍有表达；（３）ＴＧＦ－β３则在扁平瘢痕和病程在１ａ以上者及女性组的增生性瘢痕中表达较强；（４）ＴＧＦ－βｓ在不同年龄组的增生性瘢痕中表达差异无显著意义；（５）ＴＮＦ－α在增生性瘢痕中表达较低，而在扁平瘢痕中表达较高。结论（１）ＴＧＦ－β１，２表达增强、而ＴＧＦ－β３ＴＮＦ－α表达减低与增生性瘢痕的形成有关，瘢痕的延迟成熟与软化也与ＴＧＦ－β１，２的持久表达有关；（２）年龄因素不影响ＴＧＦ－βｓ的表达；（３）女性ＴＧＦ－β３的表达较强，提示女性有比男性较强的抗瘢痕增生能力，值得进一步观察验证。
Objective To investigate the expression and meaning of TGF-β s & TNF-α in scar.Methods 47 cases of different kinds of scars and 16 cases of normal skin tissues have been detected immunohistochemically,and then a statistical analysis on the groups based on the type and the time of scarring as well as the age and sex of the patients has been done.Results (1) There is no positive expression of TGF-β s in normal tissues;(2)In the hypertrophic scar there are higher expression of TGF-β 1,2 .There are still some expression of TGF-β 1,2 more than one year or even more than five years later;(3)TGF-β 3 expressed highly in the flat scars and some hypertrophic scars which formed more than one year,also done in the female group;(4) There is no difference among the expressions of TGF-β s in different age groups;(5) The expression of TGF-α is lower in the hypertrophic scar in comparison with the flat scar.Conclusions (1) Higher expressions of TGF-β 1,2 are probably related to hypertrophic scar,the delayed maturing and softening of scar also related to the existence of long duration of TGF-β 1,2 as well as the loweer expression of TGF-β 3 and TNF-α;(2) The age did not affect on the expression of TGF-β s ;(3) Higher expression of TGF-β 3 in the female group indicated that the female have stronger ability of resistance to scarring than that of the male,it is evaluable to observe and demonstrate.
出处
《武警医学》
CAS
1999年第4期191-193,共3页
Medical Journal of the Chinese People's Armed Police Force
关键词
瘢痕
TNF-Α
TGF-βs
免疫组化
Scar Transfoming growth factor-β Tumor necrosis factor-α Immunohistochemistry.
