摘要
目的:观察晚发型胎儿生长受限(fetal growth restriction,FGR)患者胎盘绒毛微血管的体视学变化,探讨FGR的发病机制。方法:FGR组和对照组的胎盘组织标本各15例,应用免疫组织化学法抗CD34标记血管内皮细胞显示血管,测试胎盘绒毛内微血管的长度密度和体积密度。结果:抗CD34几乎标记胎盘绒毛所有的血管。两组微血管长度密度的差异无统计学意义(P>0.05),FGR组微血管体积密度小于对照组,差异有统计学意义(P<0.05)。结论:胎盘绒毛微血管管腔缩窄引起胎盘微循环血量减少,可能导致FGR的发生。
Objective To analyze the stereological changes of placental villous microvasculature in late- onset fetal growth restriction （FGR） and reveal its pathogenesis. Methods Placental tissues were obtained from 15 FGR patients and 15 normal pregnant women. Immunohistochemistry was used to detect CD34 stained capillaries in placenta. And stereological measurement of the full-term placental villous capillary was evaluated with anti-CD34 labeled vascular endothelial cells. Results Nearly all placental villous capillaries of placental villous were CD34 positive. The length density of villous capillaries showed no statistically difference between two groups （P〈0.05）, while the volume density of villous capillaries in FGR group was significantly decreased （P〈0.05）. Conclusion Reduction of blood flow in the placental terminal villous microcirculation arising from vasoconstriction of capillary vessels may lead to the genesis of FGR.
出处
《实用医学杂志》
CAS
北大核心
2010年第17期3135-3137,共3页
The Journal of Practical Medicine
