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人乳头瘤病毒检测在宫颈疾病中的诊断价值 被引量:8

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摘要 目的探讨人乳头瘤病毒(HPV)检测在宫颈疾病中的诊断意义。方法采用荧光定量PCR法对妇科门诊598例患者进行13种高危型HPV检测,并进行阴道镜、宫颈组织病理活检等检测,分析宫颈疾病的类型、HPV的感染率及两者的关系。结果 598例患者中HPVDNA阳性236例(39.5%),其中通过病理活检证实为慢性炎症88例,宫颈癌及癌前病变148例。结论高危型HPV是诱发宫颈癌的重要因素,根据HPV的检测结果进行病理组织学检查,能够提高宫颈癌病变的早期检出率。
出处 《检验医学与临床》 CAS 2010年第16期1741-1742,共2页 Laboratory Medicine and Clinic
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参考文献5

  • 1Pao CC,ISeng CI,Lin CY,et al.Different expression of telomerase activity in human cervical intraepithelial neoplasia lesions[J].J Clin Oncol,1997,15(5):1932-1936.
  • 2李素红,王全红.HPV与宫颈癌的研究进展[J].肿瘤研究与临床,2005,17(6):430-432. 被引量:21
  • 3Torres LA,Pojo HG,Torres RA,et al.Cervical cancer:Current view of its epidemiology and risk factors[J].Gynecol Obstet Mex,2004,72:466-474.
  • 4刘筑玉,李建梅,范燕红,姜亚杰.432例HPV检测结果和宫颈病变的关系分析[J].中国妇幼保健,2009,24(14):1919-1920. 被引量:11
  • 5Ferrera A,Velema JP,Figueroa M,et al.Human papilomavirus infection,cervical dysplasia and invasive cervical cancer in Honduras:a case-control study[J].Int J Cancer,1999,82(6):799-802.

二级参考文献30

  • 1Rao PH, Arias Pulido H, Ln XY. Chromosomal amplifications, 3q gain and deletions of 2q33 - q37 are the frequent genetic changes in cervical carcinoma [J]. BMC Cancer, 2004, 4 (1): 5
  • 2Zur Hausen H. Human papilloma virus: A possible role in squamous cell carcinoma [ J]. Current Topics in Microbiology and Immunology, 1976, 78:1
  • 3Lang J H.To receive the global chanllenge and opportunity for preventing cervical cancer[J].Chin J Obstet Gynecol,2002,37:129-131.
  • 4David B,Claire C,Mohamed M,et al.Deletion of the FHIT gene in neoplastic and invasive cervical lesions is related to high-risk HPV infection but is independent of histopathological features[J].Pathol,2000,192:502-510.
  • 5Ferber M J,Montoya D P,Yu C,et al.Integrations of the hepatitis B virus (HBV) and human papillomavirus (HPV) into the human telomerase reverse transcriptase (hTERT)gene in liver and cervical cancer[J].Oncogene,2003,22(24):3813-3820.
  • 6Jacobs M V,Zielinski D,Meijer C J,et al.A simplified and reliable HPV testing of archival Papanicolaou-stained cervical smears:application to cervical smears from cancer patients starting with cytologically normal smears[J].Br J Cancer,2000,82(8):1421-1426.
  • 7Hopman A H,Smedts F.Transition of highgrade cervical intraepithelial neoplasia to micro-invasive carcinoma is characterized by chromosome abnormalities[J].J Pathol,2004,202 (1):231.
  • 8Christopher R H,Keith A C,Carol L K S,et al.Chromosome 3p tumor-suppressor gene alterations in cervical carcinomas[J].Molecular Carcinogenesis,2001,30:159-168.
  • 9Mougin C,Hunbey O,Gay C,et al.Human papilloma viruses,cell cycle and cervical cancer[J].J Gynecol Obstet Biol Reprod(Paris),2000,29(1):13-20.
  • 10Clarke B,Chetty R.Cell cycle aberrations in the pathogenesis of squamous cell carcinoma of the uterine cervix[J].Gynecol Oncol,2001,82(2):238-246.

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