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2型糖尿病合并冠心病与唾液酸及炎性反应蛋白的相关性 被引量：4

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摘要 目的通过观察2型糖尿病(T2DM)及合并冠心病(CHD)患者外周血唾液酸(SA)及炎性反应蛋白水平变化,探讨SA及C-反应蛋白(CRP)在T2DM合并CHD中的相关性及其临床价值。方法选择临床确诊的住院和门诊T2DM患者159例,分为T2DM组(81例)和T2DM合并CHD组(78例)。采用酶法检测血清SA及乳胶增强免疫(超敏)比浊法检测血清高敏-CRP(hs-CRP)水平,进行对比及相关分析。结果 T2DM合并CHD患者BMI和SBP水平及病程显著高于无并发症患者(P<0.05);T2DM合并CHD患者的外周血SA及hs-CRP水平显著高于无并发症患者(P<0.05);T2DM合并CHD组外周血SA水平与hs-CRP水平呈显著性正相关(r=0.491,P<0.05)。结论 T2DM患者体内存在SA及CRP的异常表达,合并CHD患者更为显著,且二者具有显著相关性。SA及CRP参与了T2DM合并CHD的发生发展,此为早期干预T2DM患者合并CHD提供了理论依据。
作者 杜玉秀
机构地区 东营市第二人民医院
出处 《四川医学》 CAS 2010年第8期1165-1166,共2页 Sichuan Medical Journal
关键词 2型糖尿病 冠心病 唾液酸 C-反应蛋白 相关性
分类号 R446.6 [医药卫生—诊断学] R587.1 [医药卫生—内分泌]
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参考文献13

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二级参考文献15

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共引文献199

同被引文献60

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引证文献4

二级引证文献36

四川医学
2010年 第8期

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