摘要
目的观察慢性肾哀竭(CRF)患者体内炎症因子的表达及血液灌流对其的清除效果,探讨血液灌流对慢性肾衰患者微炎症状态的影响。方法将60例CRF患者随机分为三组:保守治疗组,单纯血液透析组(HD组)和血液灌流联合血液透析组(HP+HD组),分别于治疗前、后采血;健康人20例作为对照组;ELISA方法检测血中C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子α(TNF-α)、白细胞介素-1(IL-1)、白细胞介素-2(IL-2)水平。结果保守治疗组、HP+HD组和HD组治疗前三组患者血CRP、IL-1、IL-2、IL-6、TNF-α水平均高于正常对照组(P<0.001),3组之间各因子水平差异无统计学意义(P>0.05);HP+HD组和HD组治疗后CRP、IL-6、TNF-α水平较治疗前降低,其中(HP+HD)组差异有统计学意义(P<0.001),HD组差异无统计学意义(P>0.05),各组CRP与IL-6、TNF-α正相关。结论慢性肾衰竭患者存在微炎症状态,血液灌流可以改善维持性血液透析患者的慢性炎症状态。
Objective To observe levels of serum inflammatory factors and effect of bemoperfusion（HP） on chronic renal failure（ARF） patients.Methods Sixty patients with simple CRF were randomly divided into heoperfusion combined with hemodialysis（HD） group（HP＋HD group,n=20） normal control group consisted of 20 healthy people.The serum CRF,IL-1、IL-2、IL-6 and INF-α levels of all patients and controls were detected by ELISA before and after the treatments.Results The serum CRP,IL-6 and TNF-α levels in both treatment groups were significantly higher than tbose in control group（P〈0.001）,and there were no significant difference between two treated groups before treatment（P〈0.05）,The levels of CRP,IL-6 and TNF-α had significant positive correlation in all groups（P〈0.001）;The serum CRP,IL-6 and TNF-α levels decreased after treatment,and there was significant difference in HP＋HD group（P〈0.001）,but not in HD group（P〈0.05）.Conclusion There are high levels of microinflammatory factors such as CRP,IL-6 and TNF-α in CRF patients.The stady also suggests that HP is an effective method to remove increased inflammatory factors in CRF patients.
出处
《四川医学》
CAS
2010年第8期1080-1082,共3页
Sichuan Medical Journal
关键词
血液灌流
慢性肾衰竭
微炎症状态
hemoperfusion
chronic renal failure
microinflammatory state
