摘要
目的研究祖师麻的化学成分。方法采用硅胶柱色谱、Pre-TLC、Pre-HPLC等方法进行分离纯化,并通过理化常数和波谱数据分析进行结构鉴定。结果分离得到6个已知的木脂素类化合物,分别鉴定为(-)-松脂酚[(-)-pinoresinol,1]、(+)-丁香树脂酚[(+)-syringaresinol,2]、(+)-里立脂素B二甲醚[(+)-lirio-rosinol-B-dimethyl ether,3]、(+)-丁香树脂酚双葡萄糖苷[(+)-syringaresinol-di-O-β-D-glucoside,4]、罗汉松脂醇(matairesinol,5)、woonenosideⅪ(6)。结论化合物3、6为从瑞香属植物中首次分离得到,化合物4、5为从祖师麻中首次分离得到。
Aim To isolate and identify the chemical constituents of Daphne giraldii Nitsche.Methods The chemical constituents were isolated by silica gel,Pre-TLC and Pre-HPLC column chromatography and their structures were elucidated by the analysis of spectral data and chemical properties.Results Six lignans compounds were isolated and their chemical structures were identified as（-）-pinoresinol（1）,（＋）-syringaresinol（2）,（＋）-liriorosinol-B-dimethyl ether（3）,（＋）-syringaresinol-di-Oβ-D-glucoside（4）,matairesinol（5）,woonenoside XI（6）,respectively.Conclusion Compounds 3,6 were isolated from Daphne genus for the first time,4 and 5 were isolated from Daphne giraldii Nitsche for the first time.
出处
《中国药物化学杂志》
CAS
CSCD
2010年第4期304-306,309,共4页
Chinese Journal of Medicinal Chemistry
关键词
祖师麻
化学成分
木脂素
结构鉴定
Daphne giraldii Nitsche
chemical constituent
lignan
structural identification
