摘要
目的:探讨丙型肝炎患者肝外组织内丙型肝炎病毒（HCV）感染状况及其意义。方法:采用免疫组化法检测9例丙型肝炎患者肾、心、胰和肠等肝外组织内HCV抗原，并与肝组织内抗原表达进行对比研究。结果:9例患者肝组织和其中6例（66.7％）的4种肝外组织检出了HCV抗原。抗原定位于组织细胞浆内。肝外组织中抗原表达阳性细胞种类多，但未见明显病变。肝组织中仅肝细胞内抗原表达阳性，病变严重。结论:肝外组织存在HCV感染。与肝组织比较，肝外组织感染可能属一种伴随状态，肝脏是感染的中心器官。肝外组织被感染可能是丙型肝炎易慢性化的重要原因之一。
Objective: To investigate the state and significance of infection of hepatitis C virus (HCV) in extrahepatic tissue in patients with viral hepatitis C. Methods: Immunohistochemical assay was used to determine the expression of HCV antigen in the kidneys, heart, pancreas, intestine and liver in 9 patients with viral hepatitis C. Results: The positive staining of HCV antigen was found in the liver of all the 9 patients but in the extrahepatic tissues in only 6 patients. The antigen was localized in the cytoplasm. It was expressed in several kinds of cells in extrahepatic tissues and there was little injury in stainable cells. In the liver, the hepatocytes with expression of HCV antigen were severely injured. Conclusion: There is extrahepatic infection of HCV. This infection plays an important role in HCV infection being apt to be chronic.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1999年第6期443-445,共3页
Journal of Third Military Medical University
