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抑肽酶对儿童体外循环致血小板激活的保护作用 被引量:3

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摘要 目的:观察体外循环所致先心心病儿童血小板激活及抑肽醉的保护作用。方法:20例非紫绀性心脏病儿童随机分为两组,A组(n=10)使用抑肽防,按5×X105IU/kg的剂量加入预充液中;B组(n=10)不用抑肽酶。检测血浆P-选择素、血栓素B2、肌酐、尿索氮、血小板计数及血球压积,记录输血总量、术中、术后24h失血量。结果:体外循环期间P-选择素和血栓素B2较转流前升高,A组明显低于B组(P<0.05),术中、术后24h输血量、失血量,A组明显少于B组(P<0.05)。血小报计数、肌酐及尿素氮两组无显著差异。结论:儿童体外循环可导致血小板激活,P-选择素释放增加,血栓素B2升高,血小板减少,抑肽酶可减轻血小板激活,抑制释放反应,保护血小板功能,减少术中、术后输血量和失血量。
出处 《第三军医大学学报》 CAS CSCD 北大核心 1999年第6期451-453,共3页 Journal of Third Military Medical University
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参考文献1

  • 1Ashraf S,Ann Thorac Surg,1997年,63卷,1期,68页

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