摘要
给早孕小鼠灌服马鞭草提取液,光镜观察细胞生长情况,细胞的变化及微血管分布情况。观察其对早孕小鼠子宫、胎盘、胎仔的影响,并作形态描述。实验表明:马鞭草能明显抑制胚胎生长使其固缩死亡,胚胎重量0 .129 ±0 .075 g ,与空白对照组比较有显著差异( P< 0 .05) ;胎仔长0 .32 ±0 .14 cm ,与空白对照组比较有极显著差异( P< 0 .01) ,与米非司酮组比较无显著差异( P> 0 .05) 。光镜显示:胎盘滋养层细胞退变凋亡,可见核固缩,染色质向细胞核膜下集聚。光镜下采用NYD1000 型图像分析Q 系统测定胎盘组织微血管分布面积,明显小于空白对照组( P< 0 .01) ,与米非司酮组比较无显著差异( P> 0 .05) 。结果表明马鞭草的抗早孕可能与其抗孕酮作用有关。
By giving the extract of \%Verbena Officinalis\% to pregnant mice, in the experiment its effects on decription of embryo, growth of cells, change of cell organs and distribution of microvessels were observed. It showed that \%Verbena Officinalis\% could inhibit the growth of embryo, and result in its pycnosis and death. Ligth microscope showed that trophoblast nucleuses of placenta shrank and chromatin condensed below nuclear membrane. The determination of microvessel area indicated that \%Verbena Officinalis\% could reduce the distribution area of placenta vessle and the result was not sighficantly different from miferpristone. It indicated that the effect of \%Verbena officinalis\% on anti early pregnancy perhaps had somthing with anti progesterone, and was worthy of further research.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1999年第3期209-211,共3页
Journal of China Pharmaceutical University
关键词
马鞭草
滋养层细胞
抗早孕
动物实验
Verbena Officinalis\%
Pregnant mice
Placenta
Trophoblast cells
