摘要
目的：观察血清Ｎ乙酰βＤ氨基葡萄糖苷酶（ＮＡＧ）活性对临床上几种肝病诊断的价值。方法：对１０３例肝病患者进行血清ＮＡＧ活性和血清总胆汁酸（ＴＢＡ）水平测定，并与传统肝功能试验做比较；选取１３０例健康体检者做血清ＮＡＧ活性参考值统计。所有项目均采用日立７１５０型自动生化分析仪测定。结果：健康人血清ＮＡＧ测值呈正偏态分布，以Ｐ９５作参考值上限为２１５Ｕ／Ｌ。血清ＮＡＧ在肝癌和酒精性肝病中阳性率分别为８００％和７００％，ＴＢＡ在肝硬变和急性肝炎中阳性率分别为９１６％和６８８％。结论：血清ＮＡＧ活性测定不仅对临床各种肝病的诊断有价值，而且其与血清ＴＢＡ同时检测能更有效地对急性酒精中毒和肝硬变进行早期鉴别诊断。
Objective:To observe the value of activity
of serum N acetyl β D glucosaminidase(NAG) in the clinical diagnosis of several liver
diseases.Methods:We determined activity of serum NAG and level of serum total bile
acid(TBA) in 103 patients with liver diseases,and the results were compared with
traditional liver function tests.We also determined activity of serum NAG in 130 healthy
individuals,and the results were used as reference values.All the tests were carried on
by using HITACHI 7150 biochemical autoanalyzer.Results:The value of serum NAG in
healthy individuals is positive skewness distribution with the upper threshold of
reference value of P 95=21 5 U/L.The positive rate of NAG is 80 0% in liver cancer
and 70 0% in alcoholic liver disease.The positive rate of TBA is 91 6% in cirrhosis and
68 8% in acute hepatitis.Conclusion:The determination of serum NAG is not only
valuable for several liver diseases but also efficient and earlier for modifying acute
alcoholism and cirrhosis when determined with serum TBA together.
出处
《中日友好医院学报》
1999年第3期167-169,共3页
Journal of China-Japan Friendship Hospital
