摘要
目的比较不同龋敏感儿童口腔变异链球菌不同基因型临床分离株对蔗糖进行酵解产生有机酸的能力。方法从不同龋敏感的3～5岁学龄前儿童口腔变异链球菌中选取66株变异链球菌临床分离株,用气相色谱法测定高龋、中龋和无龋儿童口腔变异链球菌不同基因型临床分离株产生各有机酸的量。结果不同龋敏感儿童不同基因型变异链球菌临床分离株产生有机酸的量的差异有统计学意义(P<0.05),同一龋敏感儿童变异链球菌携带不同基因型菌株产酸量的差异也有统计学意义(P<0.05),携带基因型数目越多的菌株其产酸量越多。变异链球菌临床分离株产生乳酸、乙酸、甲酸的量的差异有统计学意义(P<0.05),乳酸多于乙酸和甲酸。结论不同龋敏感儿童口腔变异链球菌不同基因型菌株产酸力不同,携带基因型数目越多的菌株其产酸力越强。
Objective To compare the production of organic acid of different genotype Streptococcus mutans（S.mutans） isolated from children with different caries experience.Methods 66 strains of S.mutans isolated from dental plaques of children aged from 3 to 5 with different caries experience were chosen as test bacteria.The quantities of organic acid include formic acid,acetic acid and lactic acid which produced by different genotype of S.mutans,were measured by gas chromatograph.Results There were significant difference in production of organic acid among the different genotypes of S.mutans isolated from children with different caries susceptibility,and so were the strains isolated from children within the same caries susceptibility（P〈0.05）.The more genotypes the strain had,the more organic acid it produced（P〈0.05）.Among all the organic acid,the quantity of lactic acid was much more than that of formic acid and acetic acid.Conclusion There were significant difference in the ability of the strains with different genotypes to produce organic acid,and the more genotypes it has,the more organic acid it produced.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
2010年第4期404-407,共4页
West China Journal of Stomatology
基金
四川省教育厅科研基金资助项目(2002A070)
关键词
龋齿
乳牙
变异链球菌
基因型
有机酸
dental caries
deciduous tooth
Streptococcus mutans
genotype
organic acid
