摘要
目的评价盐酸氨基葡萄糖治疗膝关节原发性骨性关节炎(OA)和创伤性关节炎(TA)的临床疗效。方法 2007年2月-208年10月,应用盐酸氨基葡萄糖治疗110例膝骨性关节炎患者。OA患者88例,男33例,女55例;年龄45～77岁,平均62.5岁;病程6个月-4年。TA患者22例,男16例,女6例;年龄16～6l岁,平均42岁。2个疗程后全部患者均获随访,时间8-20个月,平均9个月。采用Lequesne指数评定膝关节功能。结果 56例患者临床治愈,临床治愈率为50.91%;48例临床症状有不同程度减轻,Lequesne指数进步≥3个等级,显效率为43.64%;总有效率为96.37%。治疗前后膝关节Lequesne指数评分改善明显,差异有统计学意义(P<0.05)。治疗期间6例患者发生不良反应,发生率为5%,未特殊处理后康复。结论盐酸氨基葡萄糖治疗OA和TA患者,临床疗效满意。
Objective To evaluate the efficacy of glucosamine hydrochloride in the treatment of primary osteoarthritis （OA） and traumatic arthritis （TA） of the knee. Methods From February 2007 to October 2008, 110 patients with primary osteoarthritis and traumatic arthritis of the knee were treated with glucosamine hydrochloride. 88 patients （33males and 55 females, aged from 45 to 77, 62.5 on average） sustained OA. The course of disease ranged from 6 months to 4 years. 22 patients （26 males and 6 females, aged from 16 to 61, 42 on average） sustained TA. All patients underwent 2 courses of oral administration of glucosamine hydrochloride, and were followed up for 8 to 20 months, 9 months on average. The Lequesne index was used to evaluate the knee function. Results Among all 110 patients, 56 were clinically cured. The clinical cure rate was 50.91%. The clinical symptoms of 48 patients relieved to various degrees with the Lequesne index improved by at least 3 levels. The effective rate was 43.64% .The total effective rate was 96.37%. There was a significant difference of Lequesne index score before and after the therapy （P〈0.05）. During treatment, adverse effect occurred in 6 patients. The adverse reaction rate was 5%, and the patients recovered without special treatment. Conclusions The efficacy of glucosamine hydrochloride in the treatment of OA and TA arthritis is satisfactory.
出处
《中国骨肿瘤骨病》
2010年第4期339-341,共3页
Chinse Journal Of Bone Tumor And Bone Disease
