摘要
用放射免疫测定法对人肝细胞癌组织中铜、锌-超氧化物歧化酶(Cu,Zn—SOD)含最进行了研究。发现人肝癌组织中Cu,Zn—SOD含量降低,且肝癌组织中该酶的含量与肝癌的分化程度有关。本文还就以上结果的生物学意义进行了探讨。
Cu, Zn-superoxide dismutase (Cu, Zn-SOD) contents in the tissues of human hepatocellular carcinoma, the corresponding adjacent tumor-free liver and the normal liver were studied. Cu, Zn-SOD content in the tumor tissue was lower than that in the corresponding adjacent tumor-free tissue and the normal liver tissue. Furthormore, Cu, Zn-SOD content in poorly differentiaed liver cancer tissue was lower than that in well differentiated liver cancer tissue.
This study indicated that decreased Cu, Zn-SOD content in the corresponding adjacent tumor-free tissue, especially in the cirrhotic liver tissue, may be responsible for the malignant change of normal liver cells. The poorly differentiated liver cancer cells may have a negative regulation which can control the multiplication and differentiation of liver cancer cells.
出处
《上海医学》
CAS
CSCD
北大核心
1990年第11期621-623,共3页
Shanghai Medical Journal
