摘要
对6例血清HAV阳性的甲肝患者,在其ALT下降后做肝穿刺,进行光镜、电镜及免疫酶标检测。光镜见肝细胞有水肿变性,门管区附近嗜酸性小体形成,同时有肝细胞增生,可见核肿大及核内假包涵体,门管区有明显的炎细胞浸润。电镜特点为线粒体高度凝聚性变或肿胀,粗面内质网作同心环层排列在线粒体周围或扩大成小囊。胞质内有髓样小体。核内有胞质突入形成的假包涵体。免疫酶标检查,由于穿刺时发病超过G周,故未找到HAAg阳性细胞。根据观察所见,作者认为甲肝功能的恢复较形态恢复为早,组织的损害时间持续较长,细胞的损害与增生往往同时存在。细胞的电镜变化,早期以内质网改变明显,恢复期以线粒体为主。此外,对甲型和乙型肝炎的区别作了简要讨论。
Liver puncture biopsy was performed in 6 serum HAV positive patients when their ALT resumed normal value. Under light microscope, the specimens showed hydropic degeneration, eosinophilic bodies formed, proliferation of hepatocytes, swelling of nuclei, and some pseudo-inclusion bodies within nuclei. Under electron microscope, there were swelling and condensed conformations in mitochondria. Some rough-endoplasmic-reticulum (RER)dilated into a vesicle and some medulla bodies were seen in cytoplasm of hepatocytes. Occasionally cytoplasm invaded into nuclei forming pseudo-inclusion body. Immunological examination of slides was negative in this stage.The authors conclude that functional recovery is earlier than morphologic recovery and histologic damage and repair occur concurrently in hepatocytes.
出处
《上海医学》
CAS
CSCD
北大核心
1990年第10期581-583,2,共3页
Shanghai Medical Journal
