摘要
本文对58例膀胱肿瘤石蜡包埋标本进行了形态定量分析检测。结果表明,核平均面积,核平均最短直径,核椭圆形因子(NEF)和形状因子(FF)与膀胱肿瘤的病理分级和分期有密切的关系。高分化或浅表性膀胱肿瘤的核平均面积和核平均最短直径较小,FF数值也较低;而低分化或浸润性膀胱肿瘤的核平均面积,核平均最短直径和FF平均显增高。上述定量性参数与膀胱肿瘤复发和患者预后明显相关,其中核平均最短直径与膀胱肿瘤复发患者预后关系最大。在膀胱肿瘤复发判断上,核平均最短直径的敏感度和特异度分别为84.2％和92.3％,在膀胱肿瘤的预后估计上。核平均最短直径的敏感度乖巧特异变分别为79.2％和100％。
The quantitative cellular morphometry of paraffin-embedded tumor specimens from 58 patients with bladder tumor was carried out. It was found that in bladder tumor the average nuclear area, average shortest nuclear diameter, nuclear ellipsoidity factor (NEF) and form factor (FF) correlated well with the pathological grade and stage. In well differentiated or superficial bladder tumors, not only the average nuclear area and average shortestt nuclear diameter were relatively small but also the numerical values of NEF and FF were relatively low. In poorly differentiated or infiltrative bladder tumors, the average nuclear area, average shortest nuclear diameter, NEF and FF were much elevated. These quantitative parameters, especially the average shortest nuclear diameter, were found well linked to tumor recurrence and prognosis. In the judgement of tumor recurrence, the sensitivity and specificity of average shortest nuclear diameter were 84.2% and 92.3% respectively while in evaluation of the tumor prognosis they were 79.2% and 100%.
出处
《上海医学》
CAS
CSCD
北大核心
1990年第9期521-524,共4页
Shanghai Medical Journal
