摘要
本文研究了白血病病人血浆、红细胞和白血病细胞以及正常人血浆、红细胞、多形核细胞和单个核细胞的精氨酸酶活性。发现病人血浆、红细胞精氨酸酶活性显著高于正常人。多形核细胞精氨酸酶活性(2.04±0.49μmol/10~5细胞/h,下同)显著高于白血病细胞(0.247±0.021)(P【0.0005),而在单个核细胞中则几乎检不出该酶活性。治疗缓解后,病人血浆、红细胞、多形核细胞和单个核细胞精氨酸酶活性均比治疗前显著增加。提示白血病病人血浆及血细胞中的精氨酶活性异常可能与巨噬细胞活化及白血病细胞代谢异常有关。
Studies on the arginase activity of plasma, erythrocytes and leukemic cells(LC) in 18 patients with leukemia, and of plasma, erythrocytes, polymorphonuclear cells(PMNC) and mononuclear cells (MNC) in 29 normal individuals as control showed that the plasma and erythrocyte arginase activities in patients were higher than in control (P<0.005 and P<0.02 respectively). In control group, PMNC arginase activity was 2.04±0.49μmol/10~6 cells/hr, while it was nearly undetectable in MNC. LC arginase activity (0.247±0.021 μmol/10~6 cells/hr) was significantly lower than that in PMNC (P<0.0005). The arginase activites in leukemia patients during remission were all increased as compared with prechemotherapy. These results suggested that the increase of arginase activity during remission was possibly related to the activation of macrophages, and the low LC arginase acitivity was partly due to the abnormal arginase metabolism in leukemic cells.
出处
《上海医学》
CAS
CSCD
北大核心
1990年第7期380-382,共3页
Shanghai Medical Journal
