摘要
目的：探讨肺心病患者血中内皮素１（ＥＴ—１）和一氧化氮（ＮＯ）含量的变化及临床意义。方法：采用放射免疫分析法、硝酸还原酶法、血气分析仪、肺功能仪分别测定２５例肺心病缓解期患者和２０例正常人血中ＥＴ－１和ＮＯ水平及血气、肺功能参数。结果：肺心病患者血中ＥＴ－１明显高于正常人，而ＮＯ则明显低于正常人；肺心病患者ＥＴ－１与动脉血氧分压（ＰａＯ２）、１秒钟用力呼气量占用力肺活量比值（ＦＥＶ１％）、最大通气量（ＭＢＣ）及最大呼气中段流量（ＭＭＥＦ）呈负相关；而ＮＯ则相反，与ＰａＯ２、ＦＥＶ１％、ＭＭＥＦ呈正相关。结论：慢性缺氧所致的ＥＴ－１合成、释放增加及ＮＯ的合成、释放减少在肺动脉高压、肺心病的形成和发展中起着重要作用。
Objective: Toexplorethechangesandsignificanceofplasmaendothelin1(ET1)andnitricoxide(NO)levelsinpatientswithchronicpulmonaryheartdisease. Methods: PlasmaET1andNOlevelsweremeasuredin25casesofchronicpulmonaryheartdiseaseand20normalsubjectcases,andcorrelatedwitharterybloodgasandlungfunctionparameters.Results;PlasmaET1levelwassignificantlyhigherandNOlevelwassignificantlylowerinpatientswithchronicpulmonaryheartdiseasethanthatofnormalsubjects.PlasmaET1levelhadasignificantnegativecorrelationwithPaO2FEV1%MBCMMEF,ButNOlevelhadasignificantpositivecorrelationwithPaO2FEV1%MMEF. Conclusion: TheincreasingET1levelandreducingNOlevelresultedfromchronichypoxiawasaimportantfactorthatmayinducepulmonaryhypertensionandpulmonaryheartdisease.
出处
《四川省卫生管理干部学院学报》
1999年第2期85-87,共3页
Journal of Sichuan Continuing Education College of Medical Sciences
