摘要
恶性卵黄囊25例,按组织形态分为典型、分化差型和混合型,年龄以11～25岁最常见,占88％。一年死亡率为96％。术后AFP测定可作为观察疗效、有无复发或转移的指标。在组织发生上本瘤与早期胚胎卵黄囊均系原始生殖纲胞衍化而来,且与生殖细胞源性其他肿瘤易混杂或并存。本瘤因分化差异和组织形态多种变化,故有1～2种典型结构(星网状结构或内胚窦结构)即可确诊本瘤。按命名原则,作者建议将其称为恶性卵黄囊瘤较为合理。
Twenty-five cases of malignant yolk sac tumor are reported. Morphologically they can be classified into typical, undifferentiated and mixed types. The 11-25 age group accounted for 88% of the cases. Most of the patients (96%) who underwent surgical resection died within one year. Alpha-fetal protein (AFP) assay may serve as a tumor marker of recurrence and/or metastasis. These tumors are derived from the embryonal yolk sac and may mix with other germ cell tumors, some of these tumors may coexist.
The morphology of several component tissues varies on account of difference in their differentiation, and the presence of one or two typical tissues (reticular patterns or endodermal sinus architecture) is sufficient to arrive at the diagnosis. According to the general guidelines of nomenclature, we think it is suitable to designate this tumor as 'malignant yolk sac tumor'.
出处
《上海医学》
CAS
CSCD
北大核心
1990年第5期261-264,311,共4页
Shanghai Medical Journal
