摘要
目的：探讨游离ＰＳＡ比值（Ｆ／Ｔ－ＰＳＡ）对Ｔ－ＰＳＡ值在４～１０μｇ·Ｌ１之间，且肛指检查（ＤＲＥ）正常的良性前列腺增生（ＢＰＨ）和前列腺癌（ＰＣ）鉴别诊断的意义。方法：对Ｔ－ＰＳＡ值在４～１０μｇ·Ｌ１之间且ＤＲＥ正常的８例ＰＣ和１０例ＢＰＨ患者的Ｆ／Ｔ－ＰＳＡ进行回顾性分析。血液中的Ｆ－ＰＳＡ和Ｔ－ＰＳＡ值均用放射免疫法测定。结果：ＰＣ组和ＢＰＨ组的Ｔ－ＰＳＡ值分别是６．２１μｇ·Ｌ１和６．１５μｇ·Ｌ１，２组相比无显著性差异（Ｐ＞０．０５），而Ｆ／Ｔ－ＰＳＡ分别是０．１１和０．２１，２组相比有显著性差异（Ｐ＜０．０１），当取Ｆ／Ｔ－ＰＳＡ阈值为＜０．１５时，鉴别诊断的准确性最高，为７７．７８％，敏感性和特异性分别是８７．５０％和７０．００％。结论：Ｆ／Ｔ－ＰＳＡ有助于鉴别Ｔ－ＰＳＡ值在４～１０μｇ·Ｌ１之间且ＤＲＥ正常的ＢＰＨ和ＰＣ，可减少不必要的活检，推荐使用Ｆ／Ｔ－ＰＳＡ阈值为＜０．１５。
bjective: The purpose of the study was to evaluate the clinical significance of the proportion of free prostate specific antigen(PSA,FPSA) to total prostate specific antigen(TPSA,F/TPSA) in differential diagnosis of prostate hyperplasia(BPH) from prostate cancer (PC) with TPSA values between 4.010.0 gL1 and normal digital rectal examination(DRE). Method: A retrospective analysis was conducted in 10 BPH patients and 8 PC patients,whose TPSA and FPSA levels had determined by radioimmunoassay. Result: The TPSA levels in PC group and BPH group were found to be 6.21 gL1and 6.15 gL1,respectively.The difference was not significant(P>0.05).The F/TPSA in the two groups were found to be 0.11 and 0.21,with a significant difference (P<0.01). When F/TPSA levels were <0.15,the sensitivity,specificity and accuracy were 87.50%,70.00% and 77.78%,respectively. Conclusion: F/TPSA was a useful method with a higher sensitivity and specificity in differential diagnosis of PC from BPH.It may reduce the unnecessary biopsies in patients with TPSA between 4.010.0gL1 and normal DRE.The suggested threshold of F/TPSA is <0.15.
出处
《南京铁道医学院学报》
1999年第2期110-112,共3页
Journal of Nanjing Railway Medical College
关键词
T-PSA
诊断
前列腺增生
前列腺肿瘤
total prostate specific antigen
free prostate specific antigen
prostatic hypertrophy
prostatic neoplasms
