摘要
本文系将人甲型肝炎(下称甲肝)病毒经胃肠遭感染白髭狨猴和静脉感染普通狨猴后,定期进行肝穿活检,从组织病理学变化,结合转氨酶及抗体的改变、大便排病毒阳性,评估肝穿活检对确诊狨猴实验性甲肝模型的价值。感染动物在光镜和电镜下肝组织均呈现肝炎病变,提示经两种不同途径给两种狨猴感染甲肝病毒,都可能成为甲肝病毒实验的动物模型。
C. jacchus and S. mystax were inoculated intravenously and orally with hepatitis A virus respectively, followed by needle biopsy of liver at regular intervals. It revealed that after the infection, the pathological lesions of hepatitis and progress of the pathological changes were found both under light and electron microscopes, associated with elevation of serum GPT and GOT, appearance of antibody and shedding of the virus in the feces. These findings suggest that both C. jacchus and S. mystax can be the animal models of human hepatitis A by intravenous or oral inoculation with hepatitis A virus.
出处
《上海医学》
CAS
CSCD
北大核心
1990年第2期96-98,125,共3页
Shanghai Medical Journal
