摘要
本文采用随机双盲对照法以左旋吡喹酮(Levopraziquantel,L-P)与吡喹酮(Praziquantel,P)一剂治疗粪检阳性的日本血吸虫病278例(139对配对),其中慢性早期(慢血)268例,晚期(晚血)10例。L-P组剂量为20mg/kg,P组为40mg/kg,一次顿服,治后4～6个月,L-P组粪检阴转率分别为94.85％、96.27％;P组粪检阴转率分别为97.06％、94.03％,(P>0.05),L-P20mg/kg治疗轻、中度感染是可行的,疗效与P40mg/kg相仿。L-P剂量小、毒副反应轻、安全、简便、有利于大规模治疗的开展。
Results of a randomized double blind trial comparing the therapeutic efficacy of single dosos of levo-praziquantel (L-P) and praziquantel (P) respectively in the treatment of 139 matched pairs of proven cases of schistoeomiasis Japonica are reported. 268 were chronic early cases and 10 were late cases. All the patients were treated with doaes of L-P 20mg/kg or P 40mg/kg. 4 and 6 months after treatment, the stool-ova negative conversion rates were 94.85% and 96.27% for the L-P group, and 97.06% and 94.03% for the P group, respectively (P>0.05). For mild and moderately infected cases L-P in a single dose of 20 mg/kg is as effective as a single dose of P 40mg/kg, more over, it produces less side effects. It is thus deemed worthy of popularization.
出处
《上海医科大学学报》
CSCD
1990年第6期469-472,共4页
Journal of Fudan University(Medical Science)
关键词
日本血吸虫病
左旋吡喹酮
schistosomiasis japonics
levo-praziquentel
stool-ova negative conversion ate
