摘要
采用 Ｋａｌｌｍａｎ 等人的诊断标准，对哈尔滨市区和富裕、双城、尚志等地农村５０ 岁以上３８０ 例普通居民手骨关节病（ Ｏｓｔｅｏａｒｔｈｒｏｓｉｓ ， Ｏ Ａ） 进行 Ｘ 线检查。结果表明，各地的手 Ｏ Ａ 检出率均超过６０ ％ 以上，病情不容轻视。利用病例对照调查法观察与中老年人手 Ｏ Ａ 相关的危险因素，发现与主食种类有关，面粉（ Ｏ Ｒ＝ ３ ．０２） 、玉米面（ Ｏ Ｒ＝ ２ ．４１） 与大米（ Ｏ Ｒ＝ ０ ．３０） 相比，是手 Ｏ Ａ 的危险因素。采用历史前瞻性调查方法，证明了主食中 Ｔ２ 毒素含量与手 Ｏ Ａ 检出率之间存在“剂量效应”联系。据此，作者认为 Ｔ２ 毒素有可能成为 Ｏ Ａ 的致病因子之一。
Degenerative changes in the hand joints were studied in 380 normal inhabitants aged 50 and above living in Harbin city,Fuyu county,Shuangcheng county and Shangzhi county.Radiographs of left hand were taken and osteoarthrosis (OA) of the hand was scored according to the new X ray grading scheme proposed by Kallman et al.Total prevalence rates of left hand were all more than 60% in mentioned above observed spots,and therefore OA state must be paid attention.The cross sectional association between radiographic OA of the hand and a variety of risk factors was observed.It was found by the statistical analysis of logistic regression that different kinds of staple foods were related to OA (i.e.wheat flour,OR=3.02;maize flour,OR=2.41;rice,OR=0.30).In the grain collected from mentioned above observed spots,the content of T 2 toxin was examined using indirect competitive ELISA method.The authous found that T 2 toxin content of staple food had a definite “dose effect” relationship with the prevalence rate of OA based on prospective study.Therefore,the T 2 toxin in the grain may be one of the causative agents of OA.
出处
《哈尔滨医科大学学报》
CAS
1999年第3期176-181,共6页
Journal of Harbin Medical University
关键词
骨关节病
病因
T-2病毒
流行病学
Osteoarthrosis
Causative agent
T 2 toxin
Epidemiology
