摘要
以二软脂酰卵磷脂(DPPC)和磷脂酰甘油(PG)(7∶3,W/W)为主要成分的人工合成肺表面活性物质(PS),添加一定比例的人羊水PS和钙离子制成混合性PS。从其表面理化特性及对离体鼠肺压力-容量环的影响等方面,分别与人工合成PS和人羊水PS作了比较。结果表明三种PS在体外均能降低表面张力,但人羊水PS和混合性PS能更好地提高小鼠的肺顺应性,其功能优于人工合成PS。因此混合性PS有可能成为PS缺乏的替代治疗制剂。
The mixed pulmonary surfactant (PS) used in this experiment was prepared from synthetic DL-α-dipalmitoylphosphatidyloholine (DPPC) and L-α-phospbatidyl-DL-glyoerol(PG) (7:3, w:w)as the main components and a small amount of natural PS from human amniotio fluid and calcium chloride. Its physicoohemical properties and effects on in vitro rat lung pressure-volume changes were compared with those of synthetic PS, DPPC and PG(7:3., w:w), and human amniotio PS, respectively. It was shown that though they all could reduce surface tension, only the mixed PS and human amniotio PS could maintain film stability under low surface tension by adsorption to the air-liquid interface rapidly, and restoring pulmonary volume efficiently. We conclude that such a mixed PS is superior to synthetic PS. It produced the physiological effects of human amniotio PS, and may serve cliicoal use.
出处
《上海医科大学学报》
CSCD
1990年第3期197-200,共4页
Journal of Fudan University(Medical Science)
关键词
表面活性物质
肺
顺应性
体外实验
pulmonary surf actant
surf ace properties
in vitro experiment
lnng compliance
