摘要
目的：观察腺苷、腺苷高钾及高钾停搏液对离体豚鼠左心房肌电－机械活动的影响。方法：采用细胞内动作电位及收缩活动同步记录。结果：腺苷停搏液先引起膜静息电位轻度下降后再升高至消失，伴收缩活动进行性减弱；高钾液灌注后引发收缩活动增强后再逐渐减弱。含腺苷两组诱导电－机械活动的消失明显快于高钾组；复灌Ｔｙｒｏｄｅ液后，其恢复也早于高钾组。结论：腺苷通过诱导膜电位超极化，减少停搏期间的能耗，对左心房肌发挥较优的保护作用，高钾液增加心肌能耗。
Aim:This study was to investigate the
influence of adenosine(1 mmol/L) with or without hyperkalemia and hyperkalemic cardioplegia
on electrical and mechanical alterations if left atrial myocytes in isolated heart working
model.Method:A model of action potential and contraction recorded in step was used in this
experiment.Result:At initital perfusion with adenosine cardioplegia,resting membrane potential
was slight hyperpolarized in the first few seconds before depolarized up to abolised and
associated with contractive activities reduced progressively.Hyperkalemic cardioplegia caused
contractive activities increased markedly prior to cardioplegic arrest.The rapidly
electromechanieal arrest can be achieved by cardioplegia with adenosine.After reperfused with
Tyrode's solution,electrical and mechanical activities recovered early at specimens
pretreatment with adenosion.Conclusion:These data suggest that adenosine lead to
hyperpolarization of membrane potential and reducded energy demand during the car
protection dioplegic arrest period,therefore improved the electromechanial work
recovery,whereas hyperkalemia increased energic cost.
出处
《中华胸心血管外科杂志》
CSCD
北大核心
1999年第3期180-181,共2页
Chinese Journal of Thoracic and Cardiovascular Surgery
基金
湖北省科委"八.五"攻关资助
关键词
腺苷
钾
电-机械活动
心肌保护
AdenosineKaliumElectromechanial activityMyocardial
