摘要
目的探讨抗原特异性ＩｇＧ抗体（ＳＩｇＧ）与二苯甲烷二异氰酸酯（ＭＤＩ）哮喘发病的关系。方法观察ＭＤＩ作业工人血清中ＳＩｇＧ水平，并将ＭＤＩ哮喘患者与正常人进行对比。结果ＳＩｇＧ平均ＯＤ值，哮喘组与接触组均显示大于对照组（ｔ值分别为１１３０，９５）。但哮喘组与接触组（ｔ＝１７５），有症状组与无症状组（ｔ＝１７６）之间差异无显著意义。ＳＩｇＧ抑制试验仅显示ＭＤＩ－ＨＳＡ（人血清白蛋白）对ＳＩｇＧ抗体有明显抑制作用。结论ＳＩｇＧ水平与ＭＤＩ引起的呼吸道症状之间有显著相关关系，且具有较高的诊断价值。
Objective TostudyrelationshipbetweenserumlevelsofIgGspecificantibody(SIgG)andincidenceofasthmacausedbyexposuretodiphenylmethanediisocyanate(MDI). Methods SerumlevelsofSIgGwereanalyzedforthepatientswithasthmaandthecontrolsinworkersexposedtoMDI. Results AverageODvalueforserumSIgGincreasedsignificantlyinthepatientswithasthmaandthoseexposedtoMDIthanthatinthecontrols( t =1130and95,respectively).But,therewasnosignificantdifferenceinODvaluesbetweenthepatientswithasthmaandtheexposedworkers( t =175)andbetweensymptomaticandasymptomaticones( t =176).SIgGinhibitiontestsshowedthatMDIHSA(humanserumalbumin)couldinhibitsignificantlytheeffectsofSIgG. Conclusion ThereexistedsignificantrelationshipbetweenserumlevelofSIgGandrespiratorysymptomscausedbyMDI,indicatingahighlydiagnosticvalueoftheformer.
出处
《中国工业医学杂志》
CAS
1999年第3期146-148,共3页
Chinese Journal of Industrial Medicine
