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新生儿血小板减少症46例临床分析 被引量:2

Clinical analysis of 46 cases of neonatal thrombocytopenia
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摘要 目的分析新生儿血小板减少的临床特点及可能原因,探讨其预防和治疗措施。方法回顾性分析本院2008年1月~2009年7月诊断新生儿血小板减少症所有患儿的临床资料。结果早发型血小板减少患儿临床上多无特殊表现,预后较好;迟发型血小板减少症多发生于早产儿,小于胎龄儿,通常由于合并严重感染所致,病情严重,需要输注血小板来治疗。结论围产期有高危因素母亲,其新生儿出生后要常规监测血常规,对于宫内发育不良或低出生体质量儿生后一旦合并感染要警惕血小板减少,甚至DIC的发生。 Objective:To analyse clinical characteristics and reasons of neonatal thrombocytopenia and to study it's preventive and therapeutic measure.Methods:We retrospectively studied clinical datus in 46 cases of thrombocytopenia from 2008 to 2009.Results:Early-onset thrombocytopenia is commonly no specific appearance and it's prognosis is good.Late-onset thrombocytopenia occur in preterm infants and small for gestational age,usually due to bacterial sepsis;it is often severe and requires treatment with platelet transfusions.Conclusions:We must monitor blood routine in those neonates whose mother were high risk during pregnancy.For intrauterine growth retardation or low birth weight infants after infection to be alert as soon as thrombocytopenia,and even the occurrence of DIC.
作者 黄晓红
出处 《中国优生与遗传杂志》 2010年第8期84-85,共2页 Chinese Journal of Birth Health & Heredity
关键词 新生儿 血小板减少 Neonate Thrombocytopenia
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  • 1邓春,吴仕孝,余加林,赵晓东.新生儿缺氧缺血性脑病血浆内皮素测定及临床意义[J].中华儿科杂志,2001,39(1):51-52. 被引量:7
  • 2王鸿利.广泛开展血小板检测及其临床应用[J].中华医学检验杂志,1996,19(3):137-138. 被引量:112
  • 3O'Malley T, Langhorne P, Etton RA, et al. Platelet size in stroke patients[J]. Stroke, 1995,26 (8): 995 - 999.
  • 4Lok S. Kaushansky K, Holly RD, et al. Cloning and expression of murme thrombopoietin eDNA and stimulation of platelet production in vivo[J]. Nature, 1994;369:565~568
  • 5De Sauvage FJ, Hass PE, Spencer SD, et al. Stimulation of megakarvocytopoiesis and thrombopoiesis by the c-Mpl ligand[J ].Nature, 1994; 369: 533 ~ 538
  • 6Sola MC, Junl SE, Calhoun DA, et al .Developmental expression of thyrombopoietin(TPO) and its receptor(c mpl) in the human fetus,and TPO serum concentrations in uomal and thrombocytcpenic infants[J ]. Pediatr Res, 1997;41:219a
  • 7Dame C, Wolber EM, Fahnenstich H, et al. Thrombopoietin (TPO) nRNA expression in hunan fetal and neonatal organs [ J ]. Pediatr Res, 1998; 44: 473 (abst r )
  • 8Sungaran R, Markovic B, Chong BH. Localization and regulation of thrombopoietin mRNA expression in human kidney, liver, bone marrow,and spleen using in situ hybridization[J ]. Blood, 1997 89( 1 ):101 ~ 107
  • 9Tahara T, Usuki K, Sato H, et al. A sensitive sandwich El ISA for measuring thrombopoietin in human serum: serum thrombopoietin leves in healthy volunteers and in patients with heamopoietic disorders[J ]. Br J Haematol, 1996: 93: 783~ 788
  • 10Wendling F, Maraskovsky E, Deblll N, et al. C-Mpl ligand is a humoral regulator of megakarycytopoiesis[J ]. Nature, 1994; 369: 571 ~574

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  • 1徐亚萍,吴苔.393例新生儿血小板减少症病因与预后分析[J].中华围产医学杂志,2006,9(4):276-278. 被引量:13
  • 2Murray NA.Evaluation and treatment of thrombocytopenia in the neonatal intensive care unit[J]. Acta Paediatr Suppl, 2002,91 (458): 74-61.
  • 3F oberts J,Stanworth S,Murray NA.Thrombocy openia in the neonate[J]. Blood P ev, 2008,22(4): 173-I 86.
  • 48ola-Visner M,Saxonhouse MA,Brown P,E.Neonataf thrombocytopenia:what we do and don't know[J].Ear].y Hum Dev,2006, 84(8):499-506.
  • 5Ferrer-Uarin F,Liu zJ,autti R,et aI.Neonatal thrombocytopenia and megakaryocytopoiesis[J]. Semin Hematol, 20f O, 47(5): 281-288.
  • 6Baer VL,Lambert DK,Henry E,et al.Severe Thrombocytopenia in the NICU[J]. Pediatrics, 2009, 124(6): e; 095-1 100.
  • 7Stanworth 8J,Cl&rke P,Watts T,et aI.Prospective, observational study of outcomes in neonates with severe thrombocybpenia[J].Pediatrics,2009, 124(5):e826-854.
  • 8Eoberts I,Murray NA. Neonatal thrombocytopenia[J].Semin Fetal Neonatal Med, 2008,1 5(4): 256-264.
  • 9薛碧萍60例血小板减少症新生儿的病因与预后[J].医护论坛,2011,8(21):160-161.
  • 10Ohristensen P D,Paul DA,Sola-Visner MC,et al.lmproving platelet transfusion practices in the neonatal intensive care unit[J].Transfusion,2008, 48(11 ): 2281-2284.

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