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(5S,6R)-2-(4-甲基)苯基-6-[(1R)-叔丁基二甲基硅氧乙基]-青霉烯-3-羧酸乙酯的合成研究

Synthesis of ethyl(5S,6R)-2-(4-methylphenyl)-6-[(1R)-tert-butyldimethylsilyloxyethyl]-penem-3-carboxylate
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摘要 A compound ethyl(5S,6R)-2-(4-methylphenyl)-6-[(1R)-tert-butyldimethylsilyloxyethy]-penem-3-carboxylate was synthesized through displacement,acylation and Wittig cyclization reaction of optically active material(3R,4R)-3-[(1R)-tert-butyldimethylsilyloxyethyl]-4-acetoxy-2-azetidi-none(4AA)upon thionocarboxlic acid.The intermediates and the target product were characterized by 1HNMR,IR,elementary analysis and MS. A compound ethyl（5S,6R）-2-（4-methylphenyl）-6-[（1R）-tert-butyldimethylsilyloxyethy]-penem-3-carboxylate was synthesized through displacement,acylation and Wittig cyclization reaction of optically active material（3R,4R）-3-[（1R）-tert-butyldimethylsilyloxyethyl]-4-acetoxy-2-azetidi-none（4AA）upon thionocarboxlic acid.The intermediates and the target product were characterized by 1HNMR,IR,elementary analysis and MS.
作者 杨静 章文军 郭磊
机构地区 河北工业大学化工学院
出处 《化学研究与应用》 CAS CSCD 北大核心 2010年第8期1054-1057,共4页 Chemical Research and Application
基金 河北省自然科学基金资助项目(B2005000007)
关键词 青霉烯 4AA (5S 6R)-2-(4-甲基)苯基-6-[(1R)-叔丁基二甲基硅氧乙基]-青霉烯-3-羧酸乙酯 合成 penem 4AA ethyl（5S 6R）-2-（4-methylphenyl）-6-[（1R）-tert-butyldimethylsilyloxyethyl]-pene-m-3-carboxylate synthesis
分类号 O623.624 [理学—有机化学]
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参考文献10

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化学研究与应用
2010年 第8期

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