摘要
目的：观察一氧化氮（ＮＯ）在家兔急性心肌梗塞中的动态变化。方法：家兔８只，制备急性心肌梗塞模型，分别于缺血前、缺血即刻、缺血后１，３，６ｈ抽血，利用镉—铜还原法测定每个时点的ＮＯ水平，借助计算机图像分析系统计算梗塞面积。结果：缺血开始后，ＮＯ迅速下降，与缺血前相比，Ｐ＜０．０１；缺血后３～６ｈＮＯ又有所回升，但仍远低于缺血前水平（Ｐ＜０．０５）。结论：在家兔实验性急性心肌梗塞中，ＮＯ总水平是降低的，其机理可能与氧分压下降、内皮细胞功能受损及酸中毒等因素有关。
Objective:We were to observe the dynamic changes of nitric oxide (NO) in myocardial infarction. Methods: The model of myocardial infarction was established in 8 rabbits. The reduction of copper-plated cardium was applied to measure the level of NO in plasma at the very beginning, 1,3, and 6 hours after ischemia. The area of infarction was measured through computer. Results: At the very beginning, the level of NO fell rapidly, even lower than 46% of the control; In 1-6 hours after ischemia, the level improved, but was still significantly lower than that of the control. Conclusion: The declination of NO level in myocardial infarction might be related to the decrease of PaO 2, endothelial cell damage, and acidosis.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
1999年第2期108-109,共2页
Journal of China Medical University
