摘要
目的:通过对重症监护病房(ICU)耐甲氧西林金黄色葡萄球菌(MRSA)感染的分析,探讨其耐药性;并观察利奈唑胺在MRSA感染中的治疗效果。方法:收集我院ICU 2007年1月～2010年1月入住ICU患者的痰、血、尿、脑脊液、中心静脉穿刺针顶端及局部引流物进行细菌学培养及药物敏感性试验。结果:我院ICU病房3年共发生MRSA 54例,绝大多数为耐药菌,万古霉素、替考拉宁和利奈唑胺对MRSA感染的敏感率均为100%。利奈唑胺组的有效率和痊愈率为78.9%和36.8%。结论:控制MRSA的感染应积极进行病原学监测、及时发现病例、合理使用广谱抗生素。利奈唑胺是MRSA感染的有效药物,且不良反应较少。
Objective： To explore the drug resistance of the infection by methicillin resistant staphylococcus aureus（MRSA） in ICU and the effect of linezolid in the treatment of MRSA. Methods： The collection of sputum, blood, urine, cerebrospinal fluid, the top and local drainage of central venous needle in from Jan 2007 to Jan 2010 in ICU were carried out, and the bacteriological culture and drug susceptibility testing were executed. Results： There were 54 patients with MRSA infection in the 3 years, most of them were drug-resistant. The sensitivity of vancomycin, teicoplanin and linezolid to MRSA infection was 100% .The efficiency and recovery rates of Linezolid were 78.9% and 36.8% respectively. Conclusion： To control the MRSA infections, we should actively engage in etiology monitoring, timely detection of cases, the rational use of broad-spectrum antibiotic. Linezolid is an effective drug for MRSA infection and the adverse reactions was few.
出处
《岭南急诊医学杂志》
2010年第4期261-262,共2页
Lingnan Journal of Emergency Medicine
