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阿奇霉素对肺炎球菌的防耐药突变浓度研究 被引量：1

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摘要 目的测定阿奇霉素对肺炎链球菌的防耐药突变浓度（MPC），以了解肺炎链球菌对阿奇霉素耐药的最低剂量。方法肉汤法富集1010CFU／mlATCC49619，采用平板二倍稀释法测定阿奇霉素对ATCC49619的最低抑菌浓度（MIC）、MIC99、初测MPC（MPCpr）及MPC。结果阿奇霉素对ATCC49619的MPC为0．49gg／ml，细菌耐药选择指数（MPC／MIC99）为4．45。结论通过调整药物剂量，可以限制对阿奇霉素耐药的肺炎链球菌突变体的富集。
作者 李艳
机构地区 江苏省昆山市中医医院药剂科
出处 《中国中医药现代远程教育》 2010年第17期262-262,共1页 Chinese Medicine Modern Distance Education of China
关键词 防耐药变异浓度 罗红霉素 阿奇霉素 肺炎链球菌
分类号 R96 [医药卫生—药理学]
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  • 1陈愉,张智洁,孙继梅,白晓红,李胜歧.4种氟喹诺酮类药物对嗜麦芽寡养单胞菌防耐药变异浓度的测定[J].中国抗生素杂志,2006,31(4):216-219. 被引量：8
  • 2李朝霞,刘又宁.细菌耐药突变选择窗理论与抗菌药物合理应用[J].中国药学杂志,2006,41(16):1201-1205. 被引量：31
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中国中医药现代远程教育
2010年 第17期

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