摘要
应用鸡败血支原体国际标准株（ＭＧＲ）和鸡副嗜血杆菌（ＨＰＧ）国际标准株Ａ型（ＨＰＧ２２１）和Ｃ型（ＨＰＧ６６８）制备了抗鸡支原体病（ＡＭ）和鸡传染性鼻炎（ＩＣ）的双价二联油乳剂灭活疫苗。通过多批次ＳＰＦ鸡免疫试验，进行了疫苗安全性、抗体产生时间及抗体动态变化规律、攻毒保护率、免疫期及现地鸡群的中间试验。结果表明，疫苗接种后１０～１５天可相继产生ＭＧ和ＨＰＧ血清抗体；接种６个月内，强毒攻击的免疫保护率为９１％～１００％；各项试验的指标不低于各自的单苗，具有很好的推广应用价值。
ThestandardstrainMGRofMycoplosmagallisepticum(MG),standardstrainsoftypeA(HPG221)andC(HPG668)ofhae4mophilusparagallinarun(HPG)wereusedtoprepareacombinedinactivatedOidadjuvantedavianMycoplasmaandinfectiouscoryzaVaccine(AMIC).Thesafety,timeandkineticofantibodiesresponsegenerated,protectiveratechallenged,durationofimmunityandfieldtestswereprogressedwiththeAMICcommbinedvaccineinseveralbatchesofSPFchickens.Thetestsresultindicatedthat,seraantibodiesagainstMGandHPGweregenerated10to15dayspostinoculation,protectiverateschallengedwereduring91%to100%winthin6monthsofimmunization.AlltestsindexofAMICcombinedvaccinesuperioreditsinterrelatedsinglevaccineofMGorHPG.
出处
《中国预防兽医学报》
CAS
CSCD
1999年第3期187-190,共4页
Chinese Journal of Preventive Veterinary Medicine
