摘要
最新研究表明miRNA在免疫系统的精细调节中发挥重要作用,本综述则重点探讨miRNA如何调节细胞因子基因的机制。细胞因子转录后水平的调节主要是通过使富含腺嘌呤/尿嘧啶元件(AU-rich element,ARE)稳定性降低,然而miRNA表达具有空间和时间上的特异性,使得其在上述过程中发挥了重要作用。深入理解miRNA调节免疫反应的机制,不仅有助于鉴定调节免疫反应的新靶标,还有助于建立基于miRNA的有效新疗法。
MicroRNAs（miRNAs） have been shown to be involved in a range of physiological responses,including development,differentiation and homeostasis.Interestingly,it is now clear that miRNAs regulate many aspects of the immune response.In this review,we discuss specific examples of regulation of cytokine genes and focus on a new mechanism involving post-transcriptional regulation via miRNAs.The post-transcriptional regulation of cytokine genes via the destabilizing activity of AU-rich elements（AREs） and miRNA is a pre-requisite for regulating the half-life of many cytokines and achieving the temporal and spatial distributions required for regulation of these genes.
出处
《生命的化学》
CAS
CSCD
北大核心
2010年第4期514-517,共4页
Chemistry of Life
基金
国家自然科学基金资助项目(30770113)资助
