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哒嗪酮的乙酰胺类化合物的合成及生物活性 被引量:4

Synthesis and Biological Activity of Acetamides Containing Pyridazinones
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摘要 2-叔丁基-4-氯-5-羟基-哒基-3(2H)-酮(3)与相应的N-烷基或N,N-二烷基氯乙酰胺(4a~41)反应,合成了2-叔丁基-5-[(N-烷基或N,N-二烷基乙酰胺)氧基]-4-氯-哒嗪-3(2H)-酮(1a~11),生物活性测定结果表明部分化合物(1a~11)具有杀虫活性。 2 - ten - Butyl - 5 - [ ( N - alkyl or N, N - dialkyl acetamide) epoxy ] - 4 -chloropyridazine - 3(2/7) - one (la ~ 11) were synthesized from the corresponding N - alkyl or N, N -dialkyl - 2 - chloroacetamide (4a ~ 41) with 2 - tert - butyl - 5 - hydroxy - 4 - chloro - pyridazine - 3 (2H) - one(3). The preliminary biological tests indicate that some compounds of (la ~ 11) show an insecticidal activity.
机构地区 湖南化工研究院
出处 《有机化学》 SCIE CAS CSCD 北大核心 1999年第2期190-194,共5页 Chinese Journal of Organic Chemistry
关键词 哒嗪酮 氯代乙酰胺 杀虫活性 杀虫剂 生物活性 pyridazine, chloroacetamide, insecticidal activity
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参考文献2

  • 1Sha J J,Foreign New Pesticide Handbook (in Chinese),1993年,130页
  • 2Paterson-Jones C,South African J Chemistry (in Chinese),1984年,37卷,4期,163页

同被引文献25

  • 1柴兵 曹松 吴琦等.含噻二唑基哒嗪酮类化合物的合成及杀虫活性.应用化学,2003,.
  • 2Enrique Ravina. ;Carmen Teran. ;Lourdes Santana. Syn- thesis of 2H - Pyridazin - 3 - ones With Aroylpiperazinyl Groups [J]. Heterocyles,Vol. 31,No. 11, 1990.
  • 3Sotelo, E. ; Fraiz, N. ; Yanez, M. ; Terrades, V. ; La- guna, R. ; Cano, E. ; Ravina, E. Synthesis and Platelet Aggregation Inhibition Activity of 5 - Substituted - 6 - phenyl - 3 (2H) - pyridazinones. Novel aspects of their biological actions [ J 1. Bioorganic and Medicinal Chemis- try, 2002, 10:2873-2882.
  • 4Karl Duty, Franz Reicheneder. 3 - Aryl - 4 - Halopyr- idazinones- (6) and Systhesis Thereof. , US Patent 3, 193,552 , 1965,4:292~.
  • 5Wu, J. ; Song, B. A. ; Chen, H. J. ; Pinaki, B. ;Hu, D. Y. ; Synthesis and Antifungal Activity of 5 - Chloro - 6 - Phenylpyridazin - 3 (2H) - one Derivatives [ J ]. Mol- ecules, 2009, 14 : 3676 - 3687.
  • 6钱旭红,曹松,宋恭华.(嗯)噻二唑哒嗪酮衍生物及其制备方法与应用:中国,CN1276373[P].2000.
  • 7Enrique Ravina. ;Carmen Teran. ;Lourdes Santana. Syn- thesis of 2H - Pyridazin - 3 - ones With Aroylpiperazinyl Groups [J]. Heterocyles,Vol. 31,No. 11, 1990.
  • 8Sotelo, E. ; Fraiz, N. ; Yanez, M. ; Terrades, V. ; La- guna, R. ; Carlo, E. ; Ravina, E. Synthesis and Platelet Aggregation Inhibition Activity of 5 - Substituted - 6 - phenyl - 3 (2H) - pyridazinones. Novel aspects of their biological actions [ J ]. Bioorganic and Medicinal Chemis- try, 2002, 10:2873 -2882.
  • 9Karl Dury, Franz Reicheneder. 3 - Aryl -4 - Halopyr- idazinones- (6) and Systhesis Thereof. , US Patent 3, 193,552 ,1965,.4, ,292.
  • 10Wu, J.; Song, B. A.; Chen, H. J.; Pinaki, B.;Hu, D. Y. ; Synthesis and Antifungal Activity of 5 - Chloro - 6 - Phenylpyridazin - 3 (2H) - one Derivatives [ J ]. Mol- ecub,.s, 2009, 14 : 3676 - 3687.

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