摘要
目的通过疲劳症状量表(Fatigue Symptom Inventory,FSI)来观察非小细胞肺癌患者化疗前后疲劳症状的变化及其影响因素。方法应用疲劳症状量表(FSI)分别观察108例完成1周期化疗的非小细胞肺癌患者化疗前后1周内疲劳状况变化,并对其中81例完成2周期同方案化疗的患者进行2周期疲劳观察。结果年龄、性别、疾病分期、既往化疗次数对FSI得分无影响,KPS评分较低,有症状、体征且影响日常生活和工作,化疗前即有较高的FSI得分,疲劳程度及疲劳对生活的影响、疲劳持续时间得分在化疗后第1周多有所加重(P<0.05)。各化疗方案对疲劳的影响无明显差异,化疗缓解率短期内对疲劳的影响也无明显差异。结论 KPS评分是影响非小细胞肺癌患者化疗前疲劳的主要因素,化疗前KPS低者FSI量表得分高,疲劳症状明显。化疗能暂时加重疲劳。三种两药联合化疗方案对疲劳的影响差别不大,肿瘤缓解率对短期内患者的疲劳无显著影响。
Objective To apply Fatigue Symptom Inventory（FSI） in evaluation of cancer-related fatigue of non-small cell lung cancer（NSCLC） patients receiving chemotherapy.Methods Cancer-related fatigue of 108 NSCLC patients was evaluated by self-scoring 13 FSI items a day before and a week after chemotherapy respectively.For 81 patients who completed two cycles of chemotherapy,the evaluation was repeated.Results Age,sex,staging of disease,frequency of chemotherapy before were not significantly associated with cancer-related fatigue in NSCLC patients.Those with lower Karnofsky Performance Score（KPS） and with symptoms or signs effecting daily life and work,got higher FSI scores.The intensity and duration of fatigue were significantly aggravated in the first week after chemotherapy（P〈0.05）,and there were no difference among different chemo-schemas.Remission rate did not affect fatigue symptom immediately.Conclusion Chemotherapy can aggravate cancer-related fatigue of non-small cell lung cancer patients temporarily,which is associated with KPS of patients but not with types of chemo-schemas and remission rate.
出处
《实用肿瘤杂志》
CAS
北大核心
2010年第4期481-485,共5页
Journal of Practical Oncology
关键词
癌
非小细胞肺/药物疗法
疲劳
药物疗法
carcinoma
non-small cell lung/drug therapy
fatigue
drug therapy
