摘要
目的：为了探讨恶性淋巴瘤（ＭＬ）患者血浆Ｄ－二聚体（ＤＤ）、血管性血友病因子（ＶＷＦ）水平变化的临床意义．方法：用ＥＬＩＳＡ双抗体夹心法对５２例ＭＬ患者血浆ＤＤ，ＶＷＦ水平进行了检测．结果：①初发ＭＬ患者血浆ＤＤ，ＶＷＦ水平［（０．１７３４±０．１１９４）ｍｇ／Ｌ，（２０４．１２±７８．８１）％］明显高于对照组［（０．１０３０±０．０２９１）ｍｇ／Ｌ，（１４７．８５±３６．２６）％，Ｐ值均小于０．０１］，且二者之间呈明显正相关（ｒ＝０．４３９，Ｐ＜０．０２）．②初发非霍奇金淋巴瘤（ＮＨＬ）患者血浆ＶＷＦ含量（２５４．２８±４４．７３）％明显高于霍奇金病（ＨＤ）组（１４６．７９±７０．５１）％和ＮＨＬ缓解组（１４９．２５±４３．９２）％，Ｐ＜０．０１，ＨＤ则无此变化．结论：①初发ＭＬ患者存在不同程度的高凝状态．②血浆ＶＷＦ含量变化对ＮＨＬ的诊断和预后有一定的参考价值．
AIM: To discuss the clinical significance of the changes of plasma D dimer(DD) and von Willebrand factor(VWF) levels in patients with malignant lymphoma(ML). METHODS: The levels of plasma DD and VWF in 52 ML patients and 30 donors were detected by the method of double antibodies ELISA. RESULTS: ① The levels of plasma DD and VWF in newly diagnosed ML patients [(0.1734± 0.1194) mg/L, (204.12±78.81)%] were markedly higher than those in normal control group [(0.1030±0.0291) mg/L,(147.85±36.26)%, P <0.01]. There was an obvious positive correlation between plasma DD levels and VWF levels in newly diagnosed ML patients( r =0.439, P <0.02). ②The levels of plasma VWF in newly diagnosed non Hodgkin's Lymphoma(NHL) patients(254.28±44.73)% were markedly higher than those in newly diagnosed Hodgkin's Disease(HD) patients[(146.79±70.51)%, P <0.01], and gradually normalized in complete remission group[(149.25± 43.92) %, P <0.01]. CONCLUSION:①There is a hypercoagulable state in newly diagnosed ML patients. ② The changes of plasma VWF levels may play a role in the diagnosis and prognosis of NHL.
出处
《第四军医大学学报》
1999年第4期340-341,共2页
Journal of the Fourth Military Medical University
