摘要
目的观察射频加温联合放射治疗中晚期宫颈癌的临床疗效。方法将80例经病理确诊的中晚期宫颈癌患者随机分为两组:放射治疗+热疗组(热疗组)40例和单纯放射治疗组(放疗组)40例。两组的放射治疗方法一样:全盆照射+盆腔四野照射+腔内后装放疗。热放组采用了射频深部热疗,每周2次,共6～10次。每次热疗均在放疗后30 min内开始。结果放疗组和热疗组的局部控制率(CR)分别为47.5%、60.0%,P<0.05有统计学意义。1和2年总生存率分别为92.5%、92.5%和82.5%、85.0%,P>0.05。近期毒副反应包括恶心和呕吐、白细胞下降、腹泻、直肠反应两组P>0.05。远期并发症仅为Ⅰ+Ⅱ,放射性直肠炎和膀胱炎发生率分别为15.0%、17.5%和2.5%、2.5%,P>0.05。结论射频加温联合放射治疗可以明显提高中晚期宫颈癌的局部控制率,未增加近期毒副反应和远期并发症。
Objective To determine the efficacy of hyperthermia combined with radiotherapy for advanced cervical cancer.Methods 80 cases of cervical carcinoma diagnosed by pathology were divided randomly into two groups,Radiotherapy ＋ hyperthermia（H＋R group） 40 cases and radiotherapy alone（RT group） 40 cases,Radiotherapies of both groups were alike： pelvic external irradiation plus intracavitary brachytherapy,H ＋R group was treated with hyperthermia,which was given 30 minutes after radiotherapy,twice per week,a total of 6 - 10times.Results Radiotherapy group and the hyperthermia group of local control rate（CR） were 47.5%,60.0%,P 0.05,1 and 2 year overall survival rates were 92.5%,92.5% and 82.5%,85.0%,P〉0.05.Recent toxicity include nausea and vomiting,leukopenia,diarrhea,rectal response,P 0.05,Long-term complications only Ⅰ ＋ Ⅱ,radiation proctitis and cystitis rate was 15.0%,17.5% and 2.5%,2.5%,P〉0.05.Conclusion Hyperthermia combined with radiotherapy in advanced cervical cancer can significantly improve the local control rate,without increasing the toxicity of the recent and long-term complications.
出处
《湖南中医药大学学报》
CAS
2010年第8期32-33,51,共3页
Journal of Hunan University of Chinese Medicine
