DNA依赖蛋白激酶生物学功能与肿瘤相关性研究进展
摘要
近年来利用现代分子生物技术检测各种肿瘤标志物和基因以探索其与肿瘤的相关性,为肿瘤综合治疗提供合理的指导已成为可能。目前,国内外有关DNA-PK的研究报道较多,本文就DNA-PK的主要生物学功能及其与肿瘤的相关研究做如下综述。
出处
《现代肿瘤医学》
CAS
2010年第8期1662-1664,共3页
Journal of Modern Oncology
参考文献31
-
1Cary RB,Peterson JT.DNA looping by KU and DNA-dependent protein kinase[J].Proc Natl Acad Sci,1997,94:4267-4272.
-
2Featherstone C,Jackson SP.Ku,a DNA repair protein with multiple cellular functions[J] ? Murat Res,1999; 434:3-15.
-
3Ma Y,Lieber MR.in vitro nonhomologous DNA end joining system Methods[J].Ensymol,2006,408:500-510.
-
4安静,徐勤枝,隋建丽,白贝,周平坤.沉默DNA-PKcs对细胞信号转导相关基因转录的影响[J].中国生物化学与分子生物学报,2005,21(5):649-655. 被引量:2
-
5Wang S,Guo M,Ouyang H,et al.The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apeptosis but not cell-cycle arrest[J].Proc Natl Acad Sci USA,2000,97:1584-1588.
-
6Burma S,Kurimasa A,Xie G,et al.DNA-dependent protein kinase independent activation of P53 in response to DNA damage[J].J Biol Chem,1999,274:17139-17143.
-
7Jack MT,Woor A,M otoyama N,et al.DNA-dependent protein kinase and checkpioint kinase synergistically activate a latent population of P53 upon DNA damage[J].J Bio Chem,2004,279:15269-15273.
-
8Nnssenzweig A,Chen C,daCesta Seares V,et al.Requirement for KU80 in growth and immunnglubulin V(D)J recombination[J].Nature,1996,382:551-555.
-
9Boskovic J,Rivera-Calzada A,Maman JD.Visualization of DNA-induced oonformational changes in the DNA repair kinase DNA-PKcs[J].EMBO J,2003,22(21):5875-5882.
-
10曲颂,梁世雄,朱小东.Ku蛋白及DNA-PK与肿瘤治疗敏感性关系的研究进展[J].现代肿瘤医学,2006,14(1):114-116. 被引量:4
二级参考文献35
-
1Jackson S P. The recognition of DNA damage. Curr Opin Genet Dev, 1996,6:19 ~ 25.
-
2Park S J, Oh E J, Yoo M A, Lee A H. Involvement of DNA-dependent protein kinase in regulation of stress-induced JNK activation. DNA Cell Biol, 2001,20:637 ~ 645.
-
3Jackson S P. Sensing and repairing DNA double-strand breaks. Carcinogenesis, 2002,23: 687 ~ 696.
-
4Gilley D, Tanaka H, Hande MP, Kurimasa A, Li G C, Oshimura M, Chen D J. DNA-PKcs is critical for telomere capping. Pro Natl Acad Sci USA, 2001,98:15084 ~ 15088.
-
5Meek K, Gupta S, Ramsden D, Lees-Miller S . The DNA-dependent protein kinase: the director at the end. Immunol Rev, 2004,200:132 ~ 141.
-
6Bailey S M, Brenneman M A, Halbrook J, Nickoloff J A, Rllrich R L, Goodwin E H. The kinase activity of DNA-PK is required to protect mammalian telomeres. DNA Repair ( Amst ), 2004,3:225 ~ 233.
-
7Beamish H J, Jessberger R, Riballo E, Priestley A, Blunt T, Kysela B, Jeggo P A. The C-terminal conserved domain of DNA-PKcs, missing in the SCID mouse, is required for kinase activity. Nucleic Acids Res, 2000,28:1506 ~ 1513.
-
8Nakanishi H, Yoshioka K, Joyama S, Araki N, Myoui A, Ishiguro S, Ueda T, Yoshikawa H, Itoh K. Iherleukin-6/soluble interleukin-6 receptor signaling attenuates proliferation and invasion, and induces morphological changes of a newly established pleiomorphic malignant fibrous histiocytoma cell line. Am J Pathol, 2004,165:471 ~480.
-
9Moll U, Lau R, Sypes M A, Gupta M M, Anderson C W. DNA-PK, the DNA-activated protein kinase, is differentially espressed in normal and malignant human tissues. Oneogene, 1999,18:3114 ~ 3126.
-
10Chen S, Wang G, Makrigiorgos G M, Price B D. Stable siRNAmediated silencing of ATM alters the transcriptional profile of HeLa cells. Biochem Biophys Res Commun, 2004, 317:1037 ~ 1044.
共引文献21
-
1隋建丽,范保星,孙敬芬,周平坤.α粒子诱发人支气管上皮细胞癌变的DNA修复基因表达谱研究[J].癌变·畸变·突变,2004,16(5):257-259. 被引量:3
-
2侯宇,李文辉,杨胜刚,秦继勇,夏群.DNA-PKcs在鼻咽癌组织中的表达及临床相关性研究[J].现代肿瘤医学,2008,16(11):1878-1881. 被引量:2
-
3余子建,孙敬芬,隋建丽,吴德昌,周平坤.DNA-PKcs反义核酸增强HeLa细胞对辐射及化疗药物顺铂的敏感性[J].中国现代医学杂志,2005,15(8):1148-1151. 被引量:5
-
4安静,徐勤枝,隋建丽,白贝,臧远胜,周平坤.DNA-PKcs失活对c-Myc蛋白表达的影响[J].军事医学科学院院刊,2005,29(4):312-315. 被引量:1
-
5安静,隋建丽,徐勤枝,周平坤.siRNA抑制DNA-PKcs表达及对HeLa细胞增殖的影响[J].癌变·畸变·突变,2005,17(6):327-331. 被引量:3
-
6陶金华,申洪,周春辉,陆药丹,邓敏.基于痰涂片巴氏染色色度学特征的肺癌脱落细胞的模式识别研究[J].中国体视学与图像分析,2007,12(2):129-133. 被引量:5
-
7余子建,徐勤枝,周丽君,隋建丽,张士猛,安静,王豫,周平坤.肝癌组织DNA-PKcs过量表达及其靶向siRNA分子的抗增殖作用[J].世界华人消化杂志,2007,15(36):3815-3821. 被引量:6
-
8吕洋,张洪林,吕亚莉,钟梅,刘琳,赵坡.结肠癌Colo205细胞系SP细胞分子标志的初步观察[J].中华肿瘤防治杂志,2008,15(7):499-502. 被引量:2
-
9郝艳艳,胡雪君,温华,康健,刘云鹏,金波,侯科佐.ERCC1、DNA-PKcs蛋白在非小细胞肺癌中的表达与预后的关系[J].中国肺癌杂志,2008,11(2):226-230. 被引量:13
-
10吕洋,张洪林,李亚卓,赵坡.结直肠癌DNA依赖蛋白激酶催化亚单位、P16表达的临床病理意义[J].中华医学杂志,2008,88(29):2025-2029. 被引量:5
-
1周晟,许三鹏,李娜萍.乳腺癌组织中DNA依赖蛋白激酶的表达变化[J].华中科技大学学报(医学版),2005,34(6):760-763. 被引量:2
-
2侯宇,李文辉,杨胜刚,秦继勇,夏群.DNA-PKcs在鼻咽癌组织中的表达及临床相关性研究[J].现代肿瘤医学,2008,16(11):1878-1881. 被引量:2
-
3王晓莉,张明,李文辉.DNA-PK亚单位Ku70、Ku80在不同分期乳腺癌中的表达情况[J].昆明医学院学报,2009,30(2):114-117. 被引量:8
-
4王晓莉,陈文林,张明,李文辉.DNA-PKcs在乳腺浸润性导管癌中的表达与病理分级的关系[J].昆明医学院学报,2009,30(1):54-56.
-
5王晓莉,陈文林,李文辉,沈国平.DNA-PKcs雌激素受体及c-erbB-2在乳腺癌中的表达及相互关系[J].昆明医学院学报,2008,29(3):18-21.
-
6余子建,隋建丽,丁映钦,曹珍山,周平坤,吴德昌.肝胆肿瘤组织中DNA依赖蛋白激酶的表达及意义[J].中华肝脏病杂志,2004,12(11):652-655. 被引量:9
-
7小肠、结肠、直肠(081509~081552)[J].中国医学文摘(肿瘤学),2008,22(3):217-222.
-
8孙建松,杨秀海,姬红培,赵睿,代喻兵.DNA依赖蛋白激酶在人喉鳞状细胞癌中的表达及意义[J].临床耳鼻咽喉头颈外科杂志,2014,28(21):1641-1644. 被引量:2
-
9李宁,张红,王燕玲,王小虎,郝冀方.DNA依赖蛋白激酶在肿瘤细胞辐射抗性中的潜在作用[J].生物物理学报,2009,0(S1):460-461.
-
10宋广叶,宋志宇,邵淑丽,王晓燕.GLUT-1和DNA-PK在卵巢浆液性肿瘤中的表达及临床意义[J].中国肿瘤,2007,16(11):953-955. 被引量:3