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PDGF-D在胃癌组织中的表达及临床意义 被引量：1

The expression and significance of PDGF-D in gastric carcinoma tissues
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摘要 目的:探讨血小板衍生生长因子-D(PDGF-D)mRNA在胃癌组织中的表达及其与临床病理特征的关系。方法:用RT-PCR方法检测58例胃癌及相对应的癌旁标本中PDGF-D的表达,分析其与临床病理特征的关系。结果:PDGF-D在胃癌组织中表达率(98.28%)明显高于癌旁组织(87.93%)(P<0.05),胃癌组织中PDGF-D表达水平(0.703±0.336)明显高于癌旁组织(0.465±0.208)(P<0.05)。PDGF-DmRNA的表达水平与胃癌的淋巴结及远处转移和复发及无瘤生存期长短有关(P<0.05),与其它临床特征无关(P>0.05)。结论:PDGF-D在胃癌的发生、发展和转移、复发中可能起着重要的作用。检测PDGF-D的表达可作为预测胃癌转移和复发的有意义指标。 Objective： To investigate the correlation between mRNA expression of PDGF-D and clinicopathological features in gastric cancer. Methods： The reverse transcription-polymerase chain reaction（RT-PCR）technique was used to examine mRNA expression of PDGF-D and in 58 pair specimens of gastric carcinoma and tissues adjacent carcinoma. Results： The positive rates of PDGF-D mRNA in gastric cancer tissues（98.28%） were significantly higher than in tissues adjacent carcinoma（87.93%） respectively（P0.05）.Then the levels of expression in gastric cancer tissues（0.703±0.336）were significantly higher than in tissues adjacent carcinoma（0.465±0.208） respectively（P0.05） .PDGF-D expression was correlated with lymph node metastasis and prognosis（P0.05）.While no correlation was found between PDGF-D and other clinical significance of gastric carcinoma（P0.05）. Conclusion： PDGF-D may play a crucial role in carcinogenesis,development,metastasis and relapse of gastric cancer.It can be used as prognostic marker of gastric cancer in clinical practice.
作者 丁苏宁 常树建 李莉华 宋明旭 周希科 吴二斌 刘志辉
机构地区 苏州大学附属第四医院肿瘤研究所
出处 《现代肿瘤医学》 CAS 2010年第8期1600-1603,共4页 Journal of Modern Oncology
基金 无锡市科技局社会发展计划(CSZ00936)
关键词 血小板衍生生长因子-D 胃癌 逆转录聚合酶链反应 platelet-derived growth factor-D gastric cancer reverse transcription-polymerase chain reaction
分类号 R730.3 [医药卫生—肿瘤]
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参考文献9

  • 1Pohlers D,Huher R,Ukana B,et al.Expression of platelet-derived growth factors C and D in the synovial membrane of patients with rheumatoid arthritis and osteoarthritis[J].Arthritis Rheum,2006,54(3):788-794.
  • 2Li M,Jendrossek V,Belka C.The role of PDGF in radiation oncology[J].Radiat Oncol,2007,2(5):1186-1194.
  • 3Erlandsson A,Brannvall K,Gnstafsdottir S,et al.Autocrine/paracrine platelet-derived growth factor regulates praliferation of neural progenitor cells[J].Cancer Res,2006,66(15):8042-8048.
  • 4Xu L,Tong R,Cochran DM,et al.Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progrossion in an orthotopic mouse model[J].Cancer Res,2005,65(13):5711-5719.
  • 5Nakamura M,Katano M,Fujimoto K,et al.A new prognostic strategy for gastric carcinoma:mRNA expression of tumor growth-related factors in endoscopic biopsy specimens[J].Ann Surg,1997,226(1):35-42.
  • 6Fischer AN,Fuchs E,Mikula M,et al.PDGF essentially links TGF-bets signaling to nuclear beta-catanin accumulation in hepatocellular carcinoma prngressian[J].Oncegene,2007,26(23):3395-3405.
  • 7Kong D,Wang Z,Sarkar SH,et al.Platelet-derived growth factor-D overexpreasion contributes to epithelial-mesanchymal transition of PC3 prostate cancer cells[J].Sten Cells,2008,26(6):1425-1435.
  • 8Kong D,Banerjee S,Huang W,et al.Mammalian target of rapamycin repression by 3,3'-diindolylmethane inhibits invasion and angiogenesis in platelet-derived growth factor-D-overexpressingPC3 cells[J].Cancer Res,2008,68(6):1927-1934.
  • 9Wang Z,Kong D,Banerjee S,et al.Down-regulation of plateletderived growth factor-D inhibits cell growth and angiogenesis through inactivation of notch-1 and nuclear factor-KB signaling[J].Cancer Res,2007,67(23):1-9.

同被引文献17

  • 1Jin H,Park M H,Kim S M.3,3'-Diindolylmethane potentiates paclitaxel-induced antitumor effects on gastric cancer cells through the Akt/FOXM1 signaling cascade[J].Oncol Rep,2015,33(4):2031-2036.DOI:10.3892/or.2015.3758.
  • 2Jin H,Li X J,Park M H,et al.FOXM1-mediated downregulation of uPA and MMP9 by 3,3'-diindolylmethane inhibits migration and invasion of human colorectal cancer cells[J].Oncol Rep,2015,33(6):3171-3177.DOI:10.3892/or.2015.3938.
  • 3Singh-Gupta V,Banerjee S,Yunker C K,et al.B-DIM impairs radiation-induced survival pathways independently of androgen receptor expression and augments radiation efficacy in prostate cancer[J].Cancer Lett,2012,318(1):86-92.DOI:10.1016/j.canlet.2011.12.006.
  • 4Ye Y,Miao S,Wang Y,et al.3,3'-diindolylmethane potentiates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of gastric cancer cells[J].Oncol Lett,2015,9(5):2393-2397.DOI:10.3892/ol.2015.3008.
  • 5Li X J,Park E S,Park M H,et al.3,3'-Diindolylmethane suppresses the growth of gastric cancer cells via activation of the Hippo signaling pathway[J].Oncol Rep,2013,30(5):2419-2426.DOI:10.3892/or.2013.2717.
  • 6Yin X F,Chen J,Mao W,et al.A selective aryl hydrocarbon receptor modulator 3,3'-Diindolylmethane inhibits gastric cancer cell growth[J].J Exp Clin Cancer Res,2012,31:46.DOI:10.1186/1756-9966-31-46.
  • 7Zhao L,Zhang C,Liao G,et al.RNAi-mediated inhibition of PDGF-D leads to decreased cell growth,invasion and angiogenesis in the SGC-7901 gastric cancer xenograft model[J].Cancer Biol Ther,2010,9(1):42-48.DOI:10.4161/cbt.9.1.10282.
  • 8Brown L,Waseem A,Cruz I N,et al.Desmoglein 3 promotes cancer cell migration and invasion by regulating activator protein 1 and protein kinase C-dependent-Ezrin activation[J].Oncogene,2014,33(18):2363-2374.DOI:10.1038/onc.2013.186.
  • 9Najy A J,Won J J,Movilla L S,et al.Differential tumorigenic potential and matriptase activation between PDGF B versus PDGF D in prostate cancer[J].Mol Cancer Res,2012,10(8):1087-1097.DOI:10.1158/1541-7786.MCR- 12-0071.
  • 10Okada A,Yaguchi T,Kanno T,et al.PDGF-D/PDGF-ββ receptor-regulated chemotaxis of malignant mesothelioma cells[J].Cell Physiol Biochem,2012,29(1/2):241-250.DOI:10.1159/000337605.

引证文献1

现代肿瘤医学
2010年 第8期

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