摘要
本研究测定了６８例ＮＩＤＤＭ患者及３６例健康对照的血糖、血脂、ＨｂＡ１Ｃ、２４ｈ动态血压及白天、夜间尿白蛋白排泄率（ＵＡＥＲ）。将ＮＩＤＤＭ患者按２４ｈＵＡＥＲ均值分成正常尿白蛋白组、微白蛋白尿组及临床肾病组。我们发现尿白蛋白正常的ＮＩＤＤＭ患者虽然偶侧血压与健康对照可比，但其动态收缩压２４ｈ及夜间均值已较健康对照升高，且与相应的ＵＡＥＲ显著相关。随肾病程度的加重，血压、心率逐渐增加，其昼夜变异率逐渐减小，血压与ＵＡＥＲ的相关性越来越密切。多元逐步回归分析显示血压、ＨｂＡ１Ｃ、病程是对ＵＡＥＲ有显著作用的因素。本研究说明血压升高在ＮＩＤＤＭ患者糖尿病肾病（ＤＮ）始发机制及其发展过程中起重要作用。
The blood sugar.plasma lipids.HbAIC.ambulatory blood pressure (AMBP) were measured on 68 NIDDMpatients and 36 healthy controls. The patients were divided into three groups according to the 24hour meanurinary albumin excretion rate (UAER):the normoalbuminric group.the microalbuniinric and the clinical diabeticnephropathy group. We found that the increase of AMBP preceded the abnormalities of UAER in NIDDM. Whenthe severity of nephropathy was increased,the AMBP.anibulatory heart rate (AHR)were higher. theirpercentages of day.night changes were lower, and these factors were more significantly related to UAER.Multiple linear regression suggested that blood pressure.HbAIC and duration of disease were significantlyrelated to UAER. Our study demonstrate that the elevated blood pressure plays an important role in initiationand progression of DN
出处
《重庆医科大学学报》
CAS
CSCD
1999年第1期20-24,共5页
Journal of Chongqing Medical University
