摘要
目的:观察活血化瘀中药对通里攻下中药在治疗不完全性小肠梗阻方面的增效作用。方法:采用贯穿缝扎末端回肠肠管的方法建立大鼠不完全性小肠梗阻模型。荧光分光光度法测定血浆NO含量及小肠上皮细胞内Ca2+浓度;比色法测定血浆及肠组织MDA、SOD含量;观察细菌移位及肠组织病理形态学的变化。结果:模型组NO含量、Ca2+浓度、MDA含量显著增加,SOD活性显著下降,细菌移位明显,肠组织损伤加重。大承气汤组、复方丹参组及活血承气组能够降低NO含量、Ca2+浓度、MDA含量,升高SOD活性,减轻细菌移位及肠组织损伤,其中活血承气组最明显。结论:活血化瘀中药对通里攻下中药在治疗不完全性小肠梗阻方面有增效作用。
Objective：To observe synergic effect of activating blood and dispersing stasis herbs on purgative herbs in treating incomplete intestinal obstruction.Methods：Healthy Wistar rats were randomly divided into 6 groups.The 1/2 terminal ileum of rat was ligated as incomplete intestinal obstruction model.NO level in plasma and [Ca2＋] concentration in intestinal epithelial cells were detected by fluorospectrophotometry,MDA content and SOD activity in plasma and intestinal tissue were measured by chromatometry,bacteria migration and intestinal injury were observed.Results：Levels of NO,Ca2＋,MDA,bacteria migration and intestinal injury were increased and SOD activity was decreased significantly in model group.Dachengqi decoction,Fufangdanshen decoction and Huoxuechengqi decoction can antagonize the change of above indexes,the action of Huoxuechengqi decoction is the most siginificant.Conclusion：Herbs of activating blood and dispersing stasis can synergize the effect of purgative herbs in treating incomplete intestinal obstruction.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2010年第3期1-3,共3页
Pharmacology and Clinics of Chinese Materia Medica
基金
天津市科委“十五”重点项目(023111511-1)
关键词
大承气汤
复方丹参
活血承气合剂
不完全性小肠梗阻
Dachenqi Decoction
Fufangdanshen
Huoxuechengqi decoction
incomplete intestinal obstuction
