摘要
目的探讨上尿路结石致急性梗阻性肾功能不全时血清半胱氨酸蛋白酶抑制剂C(CysC)水平变化及其与预后的关系。方法比较正常对照组及手术组间的差异,以及术前与术后CysC的变化,同时测定血清肌酐(SCr)、尿素氮(BUN)。结果术前CysC显著高于正常对照组(P<0.01),术后CysC显著低于术前(P<0.01);术前、术后CysC变化与SCr、BUN呈正相关。结论上尿路结石致急性梗阻性肾功能不全时血清半胱氨酸蛋白酶抑制剂C变化与肾功能的改变有较明显的相关性。CysC可以作为上尿路结石致急性梗阻性肾功能不全时解除梗阻术后肾功能恢复情况的监测指标之一。
Objective The aim of the study is to assess the change of serum cystatin C in acute renal insufficiency from proximal urinary tract calculi and the clinic significance relationship with the prognosis of the disease.Methods There were 47 patients in the treatment group,29 male and 18 female,with the mean age of 47 year-old（range 16 to 71 years）,and there were 43 cases in the control group,with the renal function is normal.we compared the difference between the two groups as well as the change of serum cystatin C,the serum creatinine and urea nitrogen was assayed at the same time.Results The pre-operative Cystatin C was significantly higher than the control group（P0.01）,the Postoperative Cystatin C was significantly lower than the control group（P0.01）,the perioperative cystatin C level has a positive correlation with serum creatinine and urea nitrogen.Conclusions Serum cystatin C has an obviously correlation with the change of renal function in the situation of acute renal insufficiency from proximal urinary tract calculi,and it can be regraded as on of monitoring indicator of renal function recovery while the obstruction of the urinary tract was released.
出处
《中华腔镜泌尿外科杂志（电子版）》
2010年第4期52-54,共3页
Chinese Journal of Endourology(Electronic Edition)
