摘要
目的:总结内质网应激与未折叠蛋白反应的国内外研究进展,阐述其分子机制和内质网应激相关性的细胞存活及凋亡途径。方法:应用PubMed及CNKI期刊全文数据库检索系统,以"内质网应激、未折叠蛋白反应、凋亡"为关键词,检索1990-01-2010-01相关内质网应激与未折叠蛋白反应等文献,最后纳入分析24篇。结果:内质网是真核细胞中重要的细胞器,是新合成跨膜蛋白和分泌蛋白折叠与成熟的加工厂。未折叠或错误折叠蛋白在内质网大量蓄积可以导致内质网应激,激活未折叠蛋白反应。未折叠蛋白反应是一种保守性细胞自我保护性措施,通过促进内质网对蓄积在网腔内的错误折叠或未折叠蛋白质的处理,使细胞功能恢复正常并使之存活;但是,过强或者持续时间过久的内质网应激可引起细胞凋亡。结论:内质网应激与未折叠蛋白反应的分子机制已比较清楚,但仍存在问题需进一步研究。
OBJECTIVE： To summarize the advances of domestic and foreign research on endoplasmic reticulum stress and unfolded protein response,to review its molecular mechanism and the pathways of the cell survival and apoptosis associated with endoplasmic reticulum stress.METHODS：The full text database of PubMed and CNKI were searched,and the words ＂endoplasmic reticulum stress/unfolded protein response/apoptosis＂ were used as Key words：.To retrieve the literature about endoplasmic reticulum stress and unfolded protein response from Jan.1990 to Jan.2010,and then 24 were used in analysis at last.RESULTS：The endoplasmic reticulum（ER）,an important intracellular organelle of eukary-ocyte,is the factory for folding and maturation of newly synthesized transmembrane and secretory proteins.Accumulation of unfolded or misfolded proteins in ER leads to ER stress and triggers the unfolded protein response（UPR）.UPR is a highly conserved self-protective mechanism by ameliorating the accumulation of unfolded or misfolded proteins in the ER;however if ER stress is severe or protracted,cell apoptosis may be induced.CONCLUSION：Though the molecular mechanism of endoplasmic reticulum stress and unfolded protein response is clear,there are still present some questions,and so it needs further study.
出处
《中华肿瘤防治杂志》
CAS
2010年第11期869-872,共4页
Chinese Journal of Cancer Prevention and Treatment
基金
国家自然科学基金(30870522)
关键词
内质网应激
未折叠蛋白反应
细胞凋亡
综述文献
endoplasmic reticulum stress
unfolded protein response
apoptosis
review literature
