摘要
目的探讨幽门螺杆菌相关性胃窦炎对十二指肠溃疡（ＤＵ）血清试餐胃泌素（ＭＳＧ）浓度的影响。方法对１００例ＤＵ患者进行内镜、胃粘膜组织学、幽门螺杆菌（Ｈｐ）和血清ＭＳＧ检查，并分析其相互关系。结果ＤＵ患者血清ＭＳＧ浓度（１２９．９±８７．２ｐｇ／ｍｌ）较对照组（８６．１±５１．２ｐｇ／ｍｌ）显著升高（Ｐ＜０．０１），但其升高水平在伴发的不同胃窦炎中有显著差异（Ｐ＜０．０１），即胃窦炎越重，血清ＭＳＧ越高。胃窦炎的轻重与Ｈｐ感染有关，ＤＵ患者中Ｈｐ感染率高（７５．０％），与Ｈｐ相关的胃窦炎较重，其血清ＭＳＧ升高也较明显（１３７．０±１０７．５ｐｇ／ｍｌ），但在Ｈｐ阴性的胃窦炎中，血清ＭＳＧ也随炎症的加重而升高。结论ＤＵ患者血清ＭＳＧ浓度升高可能受伴发胃窦炎的影响，Ｈｐ感染引起血清ＭＳＧ升高，可能也是通过促发或加重胃窦炎所致。
Objective This paper reports the results of our study on the action of Hp associated antral gastritis to meal stimulated gastrin(MSG) release in duodenal ulcer(DU) patients.Methods The serum MSG concentration,endoscopic,histopathologic manifestations of gastric mucosa were measured and analyzed.The Hp status was determind by culture,histology and rapid urease test.Results Comparatively,patients with DU had higher(75%)Hp positive rate and Hp associated antral gastritis,and mean level of serum MSG(129.9±87.2pg/ml,P<0.01) than controls(86.1±51.2pg/ml).The increase of serum MSG related directly with severity of antral gastritis. Conclusion The rise in serum MSG in DU patient of this study is likely due to antral gastritis.The later may be evoked or aggravated by proliferation of Hp.
出处
《中华消化内镜杂志》
1999年第1期27-29,共3页
Chinese Journal of Digestive Endoscopy
